Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone.
Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone.
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DOI：
10.1016/j.cmet.2018.05.001
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发表时间：
2018-07-03
期刊：
影响因子：
29
通讯作者：
Kanoski SE
中科院分区：
文献类型：
--
作者：
Noble EE;Hahn JD;Konanur VR;Hsu TM;Page SJ;Cortella AM;Liu CM;Song MY;Suarez AN;Szujewski CC;Rider D;Clarke JE;Darvas M;Appleyard SM;Kanoski SE
脑源性分子影响行为的经典机制包括神经元突触通讯和神经内分泌信号传导。在这里，我们提供了一个替代的神经通信机制，是相关的食物摄入量控制，涉及神经肽黑色素浓集激素（MCH）的脑室容积传输的证据。结果表明，脑室接受约三分之一的MCH产生神经元的输入。此外，MCH脑脊液（CSF）水平增加之前，夜间喂养和以下的MCH产生的神经元的化学激活。利用双病毒载体的方法，额外的结果表明，推定的CSF投射MCH神经元的选择性激活增加食物摄入。与此相反，食物摄入量减少后免疫螯合MCH内源性存在于CSF中，表明通过脑室的神经肽传递是一个生理相关的信号通路的能量平衡控制。总的来说，这些结果表明，神经CSF容量传输信号可能是一个共同的神经生物学机制的基本行为的控制。
Classical mechanisms through which brain-derived molecules influence behavior include neuronal synaptic communication and neuroendocrine signaling. Here we provide evidence for an alternative neural communication mechanism that is relevant for food intake control involving cerebroventricular volume transmission of the neuropeptide melanin-concentrating hormone (MCH). Results reveal that the cerebral ventricles receive input from approximately one third of MCH-producing neurons. Moreover, MCH cerebrospinal fluid (CSF) levels increase prior to nocturnal feeding and following chemogenetic activation of MCH-producing neurons. Utilizing a dual viral vector approach, additional results reveal that selective activation of putative CSF-projecting MCH neurons increases food intake. In contrast, food intake was reduced following immunosequestration of MCH endogenously present in CSF, indicating that neuropeptide transmission through the cerebral ventricles is a physiologically relevant signaling pathway for energy balance control. Collectively these results suggest that neural-CSF volume transmission signaling may be a common neurobiological mechanism for the control of fundamental behaviors.
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影响因子：
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