Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium.
Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium.
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微折叠细胞(M细胞)跨肠上皮细胞转运抗原对于诱导Peyer氏结中某些粘膜抗原的有效免疫反应是非常重要的。近年来，我们对影响M细胞发育和功能的因素的认识取得了实质性进展。本文着重介绍了控制M细胞功能成熟的宿主基因；这方面的知识如何使我们对M细胞在稳态和衰老过程中的生物学有了迅速的了解；M细胞上表达的分子似乎被用作“免疫监视”受体以采样肠道中的致病微生物；某些病原体似乎如何利用M细胞感染宿主；以及这些知识如何被用于将M细胞特异性地靶向M细胞以试图提高粘膜疫苗的效力。
The transcytosis of antigens across the gut epithelium by microfold cells (M cells) is important for the induction of efficient immune responses to some mucosal antigens in Peyer’s patches. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells. This review highlights these important advances, with particular emphasis on: the host genes which control the functional maturation of M cells; how this knowledge has led to the rapid advance in our understanding of M-cell biology in the steady-state and during aging; molecules expressed on M cells which appear to be used as “immunosurveillance” receptors to sample pathogenic microorganisms in the gut; how certain pathogens appear to exploit M cells to infect the host; and finally how this knowledge has been used to specifically target antigens to M cells to attempt to improve the efficacy of mucosal vaccines.
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影响因子：
2.8
作者：
Bradford, Barry M.;Sester, David P.;Mabbott, Neil A.
通讯作者：
Mabbott, Neil A.
影响因子：
5.3
作者：
de Lau, Wim;Kujala, Pekka;Clevers, Hans
通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
Phalipon, Armelle
影响因子：
32.4
作者：
Farache J;Koren I;Milo I;Gurevich I;Kim KW;Zigmond E;Furtado GC;Lira SA;Shakhar G
通讯作者：
Shakhar G
影响因子：
5.3
作者：
Bjorkblom, Benny;Padzik, Artur;Coffey, Eleanor T.
通讯作者：
Coffey, Eleanor T.