Identifying obesity indicators which best correlate with type 2 diabetes in a Chinese population.
Identifying obesity indicators which best correlate with type 2 diabetes in a Chinese population.
复制标题
确定与中国人群中 2 型糖尿病最相关的肥胖指标
DOI：
10.1186/1471-2458-12-732
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发表时间：
2012-09-01
影响因子：
4.5
通讯作者：
Yang JK
中科院分区：
文献类型：
--
作者：
Xin Z;Liu C;Niu WY;Feng JP;Zhao L;Ma YH;Hua L;Yang JK
背景肥胖已被证明是2型糖尿病（T2 D）的预后指标;然而，不同肥胖指标在检测T2 D中的作用仍存在争议。本研究评价了中国人群中未确诊的糖尿病患者的体质指数（BMI）、腰围（WC）、腰臀比（WHR）和腰高比（WHTR）对T2 D的检出能力。口服葡萄糖耐量试验（OGTT）用于诊断糖尿病。共分析了220例新发T2 D病例和1，868例血糖正常受试者。ROC曲线分析被用来比较不同的肥胖指标与T2 D的关联，并确定最佳的截止点的最佳预测识别T2 D在男性和女性。ResultsAll指标与T2 D在男性和女性的存在呈正相关。在女性中，WC，WHR和WHTR相似，但与BMI相比，在识别T2 D方面更好（分别为P < 0.0001，P=0.0016和P=0.0001）。在男性中，WC、WHTR和BMI相似，但WC和WHTR优于WHR（分别为P=0.0234，P=0.0101）。女性以腰围86 cm为最佳分界点，其敏感性和特异性分别为0.714和0.616，男性以腰围90 cm为最佳分界点，其敏感性和特异性分别为0.722和0.571。结论与BMI、WHR和WHTR相比，腰围是预测中国人群2型糖尿病的一个简便、准确的指标。
BackgroundObesity has been shown to be a prognostic indicator of type 2 diabetes (T2D); however, the power of different obesity indicators in the detection of T2D remains controversial. This study evaluates the detecting power of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHTR) for the presence of T2D in undiagnosed diabetics among the Chinese population.MethodsIndividuals were selected from an ongoing large-scale population-based Beijing Community Pre-Diabetes (BCPD) study cohort. The oral glucose tolerance tests (OGTT) were performed to diagnose diabetes. A total of 220 new cases of T2D and 1,868 normal blood glucose subjects were analyzed. ROC curve analyses were used to compare the association of different obesity indicators with T2D and determine the optimal cut-off points of the best predictor for identifying T2D in men and women.ResultsAll indicators positively correlated with presence of T2D in both men and women. In women, WC, WHR and WHTR were similar, but were better in identifying T2D when compared to BMI (P < 0.0001, P=0.0016 and P=0.0001, respectively). In men, WC, WHTR and BMI were similar, but WC and WHTR were better than WHR (P=0.0234, P=0.0101, respectively). For women, 86 cm was the optimal WC cut-off point, and its sensitivity and specificity were 0.714 and 0.616; for men, the optimal cut-off point was 90 cm, and its sensitivity and specificity were 0.722 and 0.571.ConclusionCompared with BMI, WHR and WHTR, WC is a simple and accurate measure for predicting T2D in the Chinese population.
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影响因子：
4.9
作者：
Deurenberg, P;Yap, M;van Staveren, WA
通讯作者：
van Staveren, WA
影响因子：
13.3
作者：
Chan, DC;Watts, GF;Burke, V
通讯作者：
Burke, V
影响因子：
158.5
作者：
Yang, Wenying;Lu, Juming;He, Jiang
通讯作者：
He, Jiang
DOI：
10.1038/oby.2001.94
发表时间：
2001-11-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Stevens, J;Couper, D;Tyroler, HA
通讯作者：
Tyroler, HA
影响因子：
5.3
作者：
Bao, Yuqian;Lu, Junxi;Xiang, Kunsan
通讯作者：
Xiang, Kunsan