Skin autofluorescence, a non-invasive marker for AGE accumulation, is associated with the degree of atherosclerosis.
Skin autofluorescence, a non-invasive marker for AGE accumulation, is associated with the degree of atherosclerosis.
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DOI：
10.1371/journal.pone.0083084
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mulder DJ
中科院分区：
文献类型：
--
作者：
den Dekker MA;Zwiers M;van den Heuvel ER;de Vos LC;Smit AJ;Zeebregts CJ;Oudkerk M;Vliegenthart R;Lefrandt JD;Mulder DJ
晚期糖基化终末产物(AGEs)可能参与动脉粥样硬化的发展，而不仅仅是糖尿病和肾脏疾病。皮肤自发荧光(AF)是AGEs的非侵入性标志物。我们研究了皮肤房颤是否在(亚临床)动脉粥样硬化中增加，并与动脉粥样硬化的程度相关，与糖尿病和肾功能无关。对2006年至2012年间223名一级(n = )或二级(n = )预防的患者进行了横断面研究。用AGE-Reader测量皮肤房颤。超声检查用于评估颈动脉和股动脉的斑块，计算机断层扫描用于计算冠状动脉钙化评分(CACs；仅用于一级预防)。一级预防患者被分成亚临床动脉粥样硬化组，定义为>；1斑块或CACS>；100(n = 67；年龄53岁[四分位数范围48-56]；49%男性)和无对照组(96；43[38-51]；55%)。二级预防是外周动脉疾病患者(60；[58-70]；73%)。亚临床动脉粥样硬化组和临床动脉粥样硬化组的皮肤房颤发生率分别为2.11[四分位数范围为1.83~2.46]和2.71[2.15~3.27]比1.87[1.68~2.12]，P = 分别为0.005和0.001。在多变量分析中，皮肤房颤与动脉粥样硬化类别的关联与年龄、性别、糖尿病、代谢综合征的存在、Framingham风险评分和肾功能无关。皮肤房颤与大多数心血管危险因素、Framingham危险评分、IMT和CACs相关。皮肤房颤在有文献记载的亚临床和临床动脉粥样硬化中增加，独立于已知的危险因素，如糖尿病和肾脏疾病。这些数据表明，AGEs可能与动脉粥样硬化的负担有关，并值得进行前瞻性研究，以调查其作为一级预防风险评估工具的临床可用性。
Advanced glycation endproducts (AGEs) may be involved in the development of atherosclerosis, beyond diabetes and renal disease. Skin autofluorescence (AF) is a non-invasive marker for AGEs. We examined whether skin AF is increased in (subclinical) atherosclerosis and associated with the degree of atherosclerosis independent of diabetes and renal function. A cross-sectional study of 223 patients referred for primary (n = 163) or secondary (n = 60) prevention between 2006 and 2012 was performed. Skin AF was measured using the AGE-Reader. Ultrasonography was used to assess plaques in carotid and femoral arteries and computed tomography for the calculation of the coronary artery calcium score (CACS; in primary prevention only). Primary prevention patients were divided into a group with subclinical atherosclerosis defined as >1 plaque or CACS>100 (n = 67; age 53 year [interquartile range 48–56]; 49% male) and without (controls; 96; 43 [38–51]; 55%). Secondary prevention were patients with peripheral arterial disease (60; 64 [58–70]; 73%). Skin AF was higher in subclinical and clinical atherosclerosis compared with controls (skin AF 2.11 [interquartile range 1.83–2.46] and 2.71 [2.15–3.27] vs. 1.87 [1.68–2.12] respectively; P = 0.005 and <0.001). In a multivariate analysis, the association of skin AF with the atherosclerosis categories was independent of age, sex, diabetes, presence of the metabolic syndrome, Framingham Risk Score, and renal function. Skin AF correlated with most cardiovascular risk factors, Framingham risk score, and IMT and CACS. Skin AF is increased in documented subclinical and clinical atherosclerosis, independent of known risk factors such as diabetes and renal disease. These data suggest that AGEs may be associated with the burden of atherosclerosis and warrant a prospective study to investigate its clinical usability as a risk assessment tool for primary prevention.
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影响因子：
2.1
作者：
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