fMRI BOLD responses to negative stimuli in the prefrontal cortex are dependent on levels of recent negative life stress in major depressive disorder.
fMRI BOLD responses to negative stimuli in the prefrontal cortex are dependent on levels of recent negative life stress in major depressive disorder.
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DOI：
10.1016/j.pscychresns.2009.12.002
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发表时间：
2010-09-30
影响因子：
2.3
通讯作者：
Heitzeg, Mary M.
中科院分区：
文献类型：
--
作者：
Hsu, David T.;Langenecker, Scott A.;Kennedy, Susan E.;Zubieta, Jon-Kar;Heitzeg, Mary M.
目前尚不清楚压力源如何调节神经生物学机制，可能有助于重性抑郁症（MDD）的异质性。诊断为MDD的未用药患者（n = 15）和单独匹配的健康对照组（n = 15）完成了压力问卷调查，并在查看情感词时进行了功能性磁共振成像研究。近期的负面生活压力源，但不是早期的生活压力/创伤的显着影响，观察到区域血氧水平依赖性活动，在呈现负面的话在MDD患者。在对照组中，应激对消极词的脑激活没有显著影响。在MDD患者中，发现双侧眶额区11 l/47/12 m呈正相关，这些区域参与代表负价刺激。在右腹外侧前额叶区45、膝下扣带回区25和延髓核中也发现了负相关，所有这些都与MDD的病理生理有关。负性记忆偏差与最近的负性生活压力呈正相关，与膝下扣带回激活呈负相关，这表明压力可能导致这些异常的机制。近期负面生活压力源的严重程度是抑郁症神经生物学和认知功能的重要调节因素，可能有助于解释该疾病的异质性。
It is poorly understood how stressors modulate neurobiological mechanisms that may contribute to the heterogeneity of Major Depressive Disorder (MDD). Unmedicated patients diagnosed with MDD (n = 15) and individually matched healthy controls (n = 15) completed stress questionnaires and were studied with functional magnetic resonance imaging while viewing emotional words. Significant effects of recent negative life stressors, but not early life stress/trauma, were observed on regional blood oxygen level dependent activity during presentation of negative words in patients with MDD. No significant effects of stress on brain activation to negative words were found in controls. In MDD patients, positive correlations were found bilaterally in orbitofrontal areas 11l/47/12m, which are involved in representing negatively-valenced stimuli. Negative correlations were also found in the right ventrolateral prefrontal area 45, subgenual cingulate area 25, and nucleus accumbens, all of which are implicated in the pathophysiology of MDD. Negative memory bias was additionally positively associated with recent negative life stress and negatively associated with subgenual cingulate activation, suggesting a mechanism by which stress may contribute to these abnormalities. The severity of recent negative life stressors is an important modifier of neurobiological and cognitive function in MDD and may help explain heterogeneity in the disorder.
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