Paraventricular thalamic nucleus: subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys.
Paraventricular thalamic nucleus: subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys.
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DOI：
10.1002/cne.21934
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发表时间：
2009-02-20
影响因子：
2.5
通讯作者：
Price, Joseph L.
中科院分区：
文献类型：
--
作者：
Hsu, David T.;Price, Joseph L.
关键词：
本研究对食蟹猴(猕猴)顺行和逆行注射示踪剂后，前额叶皮质下的联系进行了研究。顺行示踪剂注入丘脑中线背侧，显示出向伏隔核、杏仁基底核、外侧隔核和下丘脑的强烈投射。向这些区域逆行注射示踪剂，特别标记了Pa.在下丘脑、中缝背侧和中脑导水管周围灰质逆行注射示踪剂后，在下丘脑、中缝背侧和中脑导水管周围灰质可见标记神经元。PA的轴突密度较高，5-羟色胺(5-HT)和增食欲素(ORX)及促肾上腺皮质激素释放激素(CRH)免疫阳性纤维密度适中。逆行注射示踪剂结合免疫组织化学显示ORX和5-羟色胺轴突起源于下丘脑和中脑的神经元。PA投射神经元与CRH神经元定位于下丘脑、杏仁核和中脑的同一核团，但未见双重标记。PA及其5-羟色胺、ORX和CRH神经支配的联系表明，它可能在中脑和下丘脑与伏隔核、杏仁基底核和膝下皮质之间传递应激信号，作为管理应激和可能与应激相关的精神病理的回路的一部分。
The present study examines subcortical connections of Pa, following small anterograde and retrograde tracer injections in cynomolgus monkeys (Macaca fascicularis). An anterograde tracer injection into the dorsal midline thalamus revealed strong projections to the accumbens nucleus, basal amygdala, lateral septum, and hypothalamus. Retrograde tracer injections into these areas labeled neurons specifically in Pa. Following a retrograde tracer injection into Pa, labeled neurons were found in the hypothalamus, dorsal raphe, and periaqueductal gray. Pa contained a remarkably high density of axons and axonal varicosities immunoreactive for serotonin (5-HT) and orexin/hypocretin (ORX), as well as a moderate density of fibers immunoreactive for corticotropin-releasing hormone (CRH). A retrograde tracer injection into Pa combined with immunohistochemistry demonstrated that ORX and 5-HT axons originate from neurons in the hypothalamus and midbrain. Pa-projecting neurons were localized in the same nuclei of the hypothalamus, amygdala, and midbrain as CRH neurons, although no double-labeling was found. The connections of Pa and its innervation by 5-HT, ORX, and CRH suggest that it may relay stress signals between the midbrain and hypothalamus with the accumbens nucleus, basal amygdala, and subgenual cortex, as part of a circuit that manages stress and possibly stress-related psychopathologies.
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DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
2.5
作者：
AGGLETON, JP;DESIMONE, R;MISHKIN, M
通讯作者：
MISHKIN, M
影响因子：
3.3
作者：
Angeles-Castellanos, M.;Mendoza, J.;Escobar, C.
通讯作者：
Escobar, C.
DOI：
10.1196/annals.1296.005
发表时间：
2004-01-01
期刊：
STRESS: CURRENT NEUROENDOCRINE AND GENETIC APPROACHES
影响因子：
--
作者：
Abrams, JK;Johnson, PL;Lowry, CA
通讯作者：
Lowry, CA
影响因子：
2.5
作者：
BASSETT, JL;FOOTE, SL
通讯作者：
FOOTE, SL