Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study.
Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study.
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双相 II 型和单相抑郁患者言语和空间工作记忆的差异：一项 MSI 研究
DOI：
10.1186/s12888-021-03595-3
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发表时间：
2021-11-15
期刊：
影响因子：
4.4
通讯作者：
Jia Y
中科院分区：
文献类型：
--
作者：
Li Z;Chen J;Feng Y;Zhong S;Tian S;Dai Z;Lu Q;Guan Y;Shan Y;Jia Y
Depressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipolar disorder. According to diagnostic criteria of bipolar II disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and assessments, 13 bipolar II depression (BP II), 8 unipolar depression (UD) patients and 15 healthy controls (HC) were recruited in the study. We used 2-back tasks and magnetic source imaging (MSI) to test working memory functions and get the brain reactions of the participants. Compared with HC, only spatial working memory tasks accuracy was significantly worse in both UD and BP II (p = 0.001). Pearson correlation showed that the stronger the FCs’ strength of MFG-IPL and IPL-preSMA, the higher accuracy of SWM task within left FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, p = 0.031). However, the FC strength of IFG-IPL was negatively correlated with the accuracy of SWM task within left FPN in patients with BP II (r = − 0.591, p = 0.033). Our study showed that the spatial working memory of patients with whether UD or BP II was impaired. The patterns of FCs within these two groups of patients were different when performing working memory tasks.
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影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
5.7
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Berryhill ME
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4.7
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影响因子：
16.6
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Etter, Guillaume;van der Veldt, Suzanne;Williams, Sylvain
通讯作者：
Williams, Sylvain
影响因子：
3
作者：
Brinker, Jay K.;Dozois, David J. A.
通讯作者：
Dozois, David J. A.