Frontoparietal theta-gamma interactions track working memory enhancement with training and tDCS.
Frontoparietal theta-gamma interactions track working memory enhancement with training and tDCS.
复制标题
DOI：
10.1016/j.neuroimage.2020.116615
复制
发表时间：
2020-05-01
期刊：
影响因子：
5.7
通讯作者：
Berryhill ME
中科院分区：
文献类型：
--
作者：
Jones KT;Johnson EL;Berryhill ME
尽管人们对增强、保存和恢复工作记忆(WM)很感兴趣，但在促进行为持续改善方面的努力收效甚微。在这里，我们在四天的时间里将西医训练与经颅直流电刺激(Tdcs)配对到额顶神经网络。通过训练前和训练后的高密度脑电(EEG)测量，活跃的tDCs通过调节额顶叶theta振荡和伽马活动之间的相互作用来增强WM性能。前额叶刺激点和顶叶伽马活动之间的相位-幅度耦合(PAC)增加解释了行为改善，当伽马发生在前额叶theta峰附近时效果最好。这些结果首次证明，与tdcs相关的WM训练通过优化前额叶控制的振荡底物而导致行为的持久变化。
Despite considerable interest in enhancing, preserving, and rehabilitating working memory (WM), efforts to elicit sustained behavioral improvements have been met with limited success. Here, we paired WM training with transcranial direct current stimulation (tDCS) to the frontoparietal network over four days. Active tDCS enhanced WM performance by modulating interactions between frontoparietal theta oscillations and gamma activity, as measured by pre- and post-training high-density electroencephalography (EEG). Increased phase-amplitude coupling (PAC) between the prefrontal stimulation site and temporo-parietal gamma activity explained behavioral improvements, and was most effective when gamma occurred near the prefrontal theta peak. These results demonstrate for the first time that tDCS-linked WM training elicits lasting changes in behavior by optimizing the oscillatory substrates of prefrontal control.
登录
查看更多内容
影响因子：
3
作者：
Dvorak, Dino;Fenton, Andre A.
通讯作者：
Fenton, Andre A.
影响因子：
3.7
作者：
Gerber EM;Sadeh B;Ward A;Knight RT;Deouell LY
通讯作者：
Deouell LY
影响因子：
3
作者：
Cohen, Michael X.
通讯作者：
Cohen, Michael X.
影响因子：
25
作者：
通讯作者：
--
α 峰值频率的个体间和个体内变异性。
影响因子：
5.7
作者：
Haegens S;Cousijn H;Wallis G;Harrison PJ;Nobre AC
通讯作者：
Nobre AC