Altered Patterns of the Fractional Amplitude of Low-Frequency Fluctuation in Drug-Naive First-Episode Unipolar and Bipolar Depression.
Altered Patterns of the Fractional Amplitude of Low-Frequency Fluctuation in Drug-Naive First-Episode Unipolar and Bipolar Depression.
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DOI：
10.3389/fpsyt.2020.587803
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发表时间：
2020
影响因子：
4.7
通讯作者：
Xie S
中科院分区：
文献类型：
--
作者：
Chai X;Zhang R;Xue C;Li Z;Xiao W;Huang Q;Xiao C;Xie S
背景：早期和正确的诊断是治疗单相抑郁症（UD）和双相情感障碍（BD）的关键。低频波动分数幅值（fALFFs）由于可以检测大脑的自发活动，在神经精神疾病的研究中得到了广泛的应用。本研究旨在调查UD和BD患者各频段内的fALFF变化，探讨fALFF变化对认知功能的影响。方法：共纳入58例首次用药患者，包括32例UD和26例BD。计算UD患者、BD患者和健康对照（HC）慢5波段（0.01 ~ 0.027 Hz）和慢4波段（0.027 ~ 0.073 Hz）下的fALFF值。此外，我们进行了相关分析，以检验改变的fALFF值与认知功能之间的关系。结果：慢-5波段下，与HC组相比，UD组右侧小脑后叶fALFF值升高，BD组左侧颞中回（MTG） fALFF值升高。慢-4波段下，与HC相比，UD组左侧颞上回fALFF值升高，而右侧顶叶下小叶（IPL）和BD组双侧中央后回fALFF值升高。值得注意的是，与BD相比，UD组在慢-4波段下右侧IPL的fALFF值增加。此外，左MTG和右IPL的fALFF值的改变与语言流畅性测试成绩显著正相关。结论：本研究提示早期UD组和BD组脑活动发生改变，且改变与执行功能有关。fALFF值可作为诊断和鉴别UD和BD患者的潜在生物标志物。
Background: An early and correct diagnosis is crucial for treatment of unipolar depression (UD) and bipolar disorder (BD). The fractional amplitude of low-frequency fluctuations (fALFFs) has been widely used in the study of neuropsychiatric diseases, as it can detect spontaneous brain activities. This study was conducted to survey changes of fALFF within various frequency bands of the UD and BD patients, as well as to explore the effects on changes in fALFF on cognitive function. Methods: In total, 58 drug-naive first-episode patients, including 32 UD and 26 BD, were enrolled in the study. The fALFF values were calculated under slow-5 band (0.01–0.027 Hz) and slow-4 band (0.027–0.073 Hz) among UD patients, BD patients, and healthy control (HC). Additionally, we conducted correlation analyses to examine the association between altered fALFF values and cognitive function. Results: Under the slow-5 band, compared to the HC group, the UD group showed increased fALFF values in the right cerebellum posterior lobe, whereas the BD group showed increased fALFF values in the left middle temporal gyrus (MTG). Under the slow-4 band, in comparison to HC, the UD group showed increased fALFF values in the left superior temporal gyrus, whereas the right inferior parietal lobule (IPL) and BD group showed increased fALFF values in the bilateral postcentral gyrus. Notably, compared to BD, the UD group showed increased fALFF values in the right IPL under the slow-4 band. Furthermore, altered fALFF values in the left MTG and the right IPL were significantly positively correlated with Verbal Fluency Test scores. Conclusions: This current study indicated that there were changes in brain activities in the early UD and BD groups, and changes were related to executive function. The fALFF values can serve as potential biomarker to diagnose and differentiate UD and BD patients.
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影响因子：
6.6
作者：
Smelror RE;Jørgensen KN;Lonning V;Kelleher I;Cannon M;DeRosse P;Malhotra AK;Karlsgodt KH;Andreassen OA;Lundberg M;Edbom T;Cleland N;Ueland T;Myhre AM;Rund BR;Agartz I
通讯作者：
Agartz I
影响因子：
3.7
作者：
Liang MJ;Zhou Q;Yang KR;Yang XL;Fang J;Chen WL;Huang Z
通讯作者：
Huang Z
影响因子：
11.3
作者：
McNamara, Robert K.;Rider, Therese;Tso, Patrick
通讯作者：
Tso, Patrick
影响因子：
6.6
作者：
Jones, Lindsay D.;Payne, Martha E.;Messer, Denise F.;Beyer, John L.;MacFall, James R.;Krishnan, K. Ranga R.;Taylor, Warren D.
通讯作者：
Taylor, Warren D.
影响因子：
17.7
作者：
Perlis, RH;Brown, E;Nierenberg, AA
通讯作者：
Nierenberg, AA