Effects of aging on the neural correlates of successful item and source memory encoding.
Effects of aging on the neural correlates of successful item and source memory encoding.
复制标题
衰老对成功项目和源存储器编码的神经相关性的影响。
DOI：
10.1037/0278-7393.34.4.791
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发表时间：
2008-07
期刊：
影响因子：
--
通讯作者：
Cabeza R
中科院分区：
文献类型：
--
作者：
Dennis NA;Hayes SM;Prince SE;Madden DJ;Huettel SA;Cabeza R
为了研究与年龄相关的源记忆（SM）缺陷的神经基础，研究人员对年轻人和老年人进行fMRI扫描，同时对面孔、场景和人脸-场景对进行编码。通过比较随后记忆和遗忘的项目或对的编码活动来确定成功的编码活动。海马和前额叶区的成功编码活动的年龄缺陷在SM（对）中比在项目记忆（面孔和场景）中更为明显。在专门处理人脸（梭状面区）和场景（海马体旁区）的区域也发现了与年龄相关的减少，但这些减少在项目和SM上是相似的。海马体和大脑其他部分之间的功能连通性也受到衰老的影响；老年人与后皮层的连接较弱，而与包括前额叶区域在内的前皮层的连接较强。综上所述，这些结果提供了老年人SM缺陷与编码过程中海马和前额叶区域招募减少之间的联系。功能连接的发现与衰老后-前移（PASA）一致，之前在几个认知领域报道过，并与功能代偿有关。
To investigate the neural basis of age-related source memory (SM) deficits, young and older adults were scanned with fMRI while encoding faces, scenes, and face-scene pairs. Successful encoding activity was identified by comparing encoding activity for subsequently remembered versus forgotten items or pairs. Age deficits in successful encoding activity in hippocampal and prefrontal regions were more pronounced for SM (pairs) compared to item memory (faces and scenes). Age-related reductions were also found in regions specialized in processing faces (fusiform face area) and scenes (parahippocampal place area), but these reductions were similar for item and SM. Functional connectivity between the hippocampus and the rest of the brain was also affected by aging; whereas connections with posterior cortices were weaker in older adults, connections with anterior cortices including prefrontal regions were stronger in older adults. Taken together, the results provide a link between SM deficits in older adults and reduced recruitment of hippocampal and prefrontal regions during encoding. The functional connectivity findings are consistent with a posterior-anterior shift with aging (PASA), previously reported in several cognitive domains and linked to functional compensation.
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影响因子：
3.2
作者：
Cabeza, R;Locantore, JK;Anderson, ND
通讯作者：
Anderson, ND
影响因子：
3.7
作者：
Cansino, S;Maquet, P;Rugg, MD
通讯作者：
Rugg, MD
影响因子：
2.4
作者：
Chalfonte, BL;Johnson, MK
通讯作者：
Johnson, MK
影响因子：
2.9
作者：
Davidson, Patrick S. R.;Glisky, Elizabeth L.
通讯作者：
Glisky, Elizabeth L.
影响因子：
2.5
作者：
Davachi, L;Wagner, AD
通讯作者：
Wagner, AD