Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.
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DOI：
10.1002/smll.201702479
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Jeong JW
中科院分区：
文献类型：
--
作者：
Noh KN;Park SI;Qazi R;Zou Z;Mickle AD;Grajales-Reyes JG;Jang KI;Gereau RW 4th;Xiao J;Rogers JA;Jeong JW
光遗传学和药理学的结合代表了一种独特的方法，解剖神经回路具有高特异性和多功能性。然而，可用于进行这些实验的传统工具，如光纤和金属套管，由于其系绳操作和缺乏生物力学兼容性而受到限制。为了解决这些问题，一种小型化，无电池，软光流体系统，可以提供无线给药和光刺激的目标神经回路的时空控制在自由行为的动物报道。该设备将微型无机发光二极管和微流体药物输送系统与一个微小的可拉伸多通道射频天线集成在一起，这不仅消除了对笨重电池的需求，而且还提供了完全无线的、独立的光和流体输送控制。该设计实现了一个微型（125毫米3）、轻量（220毫克）、柔软、灵活的平台，从而便于在体内无缝植入和操作，而不会对自然行为造成干扰。原理验证实验和分析研究验证了完全植入式光流体系统用于自由运动动物的可行性和可靠性，展示了其在无线体内药理学和光遗传学方面的潜力。
Combination of optogenetics and pharmacology represents a unique approach to dissect neural circuitry with high specificity and versatility. However, conventional tools available to perform these experiments, such as optical fibers and metal cannula, are limited due to their tethered operation and lack of biomechanical compatibility. To address these issues, a miniaturized, battery-free, soft optofluidic system that can provide wireless drug delivery and optical stimulation for spatiotemporal control of the targeted neural circuit in freely behaving animals is reported. The device integrates microscale inorganic light-emitting diodes and microfluidic drug delivery systems with a tiny stretchable multichannel radiofrequency antenna, which not only eliminates the need for bulky batteries but also offers fully wireless, independent control of light and fluid delivery. This design enables a miniature (125 mm3), lightweight (220 mg), soft, and flexible platform, thus facilitating seamless implantation and operation in the body without causing disturbance of naturalistic behavior. The proof-of-principle experiments and analytical studies validate the feasibility and reliability of the fully implantable optofluidic systems for use in freely moving animals, demonstrating its potential for wireless in vivo pharmacology and optogenetics.
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影响因子：
4
作者：
Kim, B. J.;Kuo, J. T. W.;Meng, E.
通讯作者：
Meng, E.
DOI：
10.1126/science.1232437
发表时间：
2013-04-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kim TI;McCall JG;Jung YH;Huang X;Siuda ER;Li Y;Song J;Song YM;Pao HA;Kim RH;Lu C;Lee SD;Song IS;Shin G;Al-Hasani R;Kim S;Tan MP;Huang Y;Omenetto FG;Rogers JA;Bruchas MR
通讯作者：
Bruchas MR
影响因子：
7.4
作者：
Copits BA;Pullen MY;Gereau RW 4th
通讯作者：
Gereau RW 4th
影响因子：
56.9
作者：
Minev, Ivan R.;Musienko, Pavel;Lacour, Stephanie P.
通讯作者：
Lacour, Stephanie P.
影响因子：
48
作者：
Bruegmann, Tobias;Malan, Daniela;Sasse, Philipp
通讯作者：
Sasse, Philipp