Acute effects of using an electronic nicotine-delivery device (electronic cigarette) on myocardial function: comparison with the effects of regular cigarettes.
Acute effects of using an electronic nicotine-delivery device (electronic cigarette) on myocardial function: comparison with the effects of regular cigarettes.
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DOI：
10.1186/1471-2261-14-78
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发表时间：
2014-06-23
影响因子：
2.1
通讯作者：
Voudris V
中科院分区：
文献类型：
--
作者：
Farsalinos KE;Tsiapras D;Kyrzopoulos S;Savvopoulou M;Voudris V
近年来，电子烟作为吸烟替代品被开发和销售。然而，没有研究评估它们对心血管系统的影响。本研究的目的是研究电子烟使用对左心室功能的直接影响，并与吸烟的急性不良反应进行比较。对36名健康重度吸烟者（SM，年龄36±5岁）和40名电子烟使用者（ECIG，年龄35±5岁）在使用“中等强度”尼古丁浓度（11 mg/ml）装置7分钟前后进行超声心动图检查。测量二尖瓣血流舒张速度（E， A）、它们的比值（E/A）、减速时间（DT）、等容松弛时间（IVRT）和校正心率（IVRTc）。估计二尖瓣收缩（Sm）和舒张（Em, Am）速度。用多普勒血流（MPI）和组织多普勒血流（MPIt）计算心肌功能指数。纵向变形测量的总应变（GS），收缩期（SRs）和舒张期（SRe, SRa）应变率。两组的基线测量结果相似。SM患者吸烟后IVRT和IVRTc延长，Em和SRe降低，MPI和MPIt升高。在ECIG中，使用器械后未观察到差异。与使用后比较，ECIG的Em （P = 0.032）和SRe （P = 0.022）较高，IVRTc （P = 0.011）、MPI （P = 0.001）和MPIt （P = 0.019）较低。即使在调整心率和血压的变化后，观察到的差异也是显著的。虽然急性吸烟会导致心肌松弛延迟，但使用电子烟不会立即产生影响。应深入研究电子烟在减少烟草危害方面的作用，以确定转向使用电子烟是否会对吸烟者的健康产生长期有益影响。当前对照试验ISRCTN16974547
Electronic cigarettes have been developed and marketed in recent years as smoking substitutes. However, no studies have evaluated their effects on the cardiovascular system. The purpose of this study was to examine the immediate effects of electronic cigarette use on left ventricular (LV) function, compared to the well-documented acute adverse effects of smoking. Echocardiographic examinations were performed in 36 healthy heavy smokers (SM, age 36 ± 5 years) before and after smoking 1 cigarette and in 40 electronic cigarette users (ECIG, age 35 ± 5 years) before and after using the device with “medium-strength” nicotine concentration (11 mg/ml) for 7 minutes. Mitral flow diastolic velocities (E, A), their ratio (E/A), deceleration time (DT), isovolumetric relaxation time (IVRT) and corrected-to-heart rate IVRT (IVRTc) were measured. Mitral annulus systolic (Sm), and diastolic (Em, Am) velocities were estimated. Myocardial performance index was calculated from Doppler flow (MPI) and tissue Doppler (MPIt). Longitudinal deformation measurements of global strain (GS), systolic (SRs) and diastolic (SRe, SRa) strain rate were also performed. Baseline measurements were similar in both groups. In SM, IVRT and IVRTc were prolonged, Em and SRe were decreased, and both MPI and MPIt were elevated after smoking. In ECIG, no differences were observed after device use. Comparing after-use measurements, ECIG had higher Em (P = 0.032) and SRe (P = 0.022), and lower IVRTc (P = 0.011), MPI (P = 0.001) and MPIt (P = 0.019). The observed differences were significant even after adjusting for changes in heart rate and blood pressure. Although acute smoking causes a delay in myocardial relaxation, electronic cigarette use has no immediate effects. Electronic cigarettes’ role in tobacco harm reduction should be studied intensively in order to determine whether switching to electronic cigarette use may have long-term beneficial effects on smokers’ health. Current Controlled Trials ISRCTN16974547
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影响因子：
3.7
作者：
Caponnetto P;Campagna D;Cibella F;Morjaria JB;Caruso M;Russo C;Polosa R
通讯作者：
Polosa R
影响因子：
5.2
作者：
Bullen, C.;McRobbie, H.;Laugesen, M.
通讯作者：
Laugesen, M.
影响因子：
2.1
作者：
Merry, Audrey H. H.;Boer, Jolanda M. A.;van den Brandt, Piet A.
通讯作者：
van den Brandt, Piet A.
DOI：
10.1016/j.echo.2005.06.006
发表时间：
2005-12-01
影响因子：
6.5
作者：
Gaibazzi, N;Petrucci, N;Ziacchi, V
通讯作者：
Ziacchi, V
影响因子：
4.6
作者：
Farsalinos, Konstantinos E.;Spyrou, Alketa;Voudris, Vassilis
通讯作者：
Voudris, Vassilis