Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma.
Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma.
复制标题
DOI：
10.1167/iovs.17-21832
复制
发表时间：
2017-08-01
影响因子：
4.4
通讯作者：
Abràmoff MD
中科院分区：
文献类型：
--
作者：
Guo Z;Kwon YH;Lee K;Wang K;Wahle A;Alward WLM;Fingert JH;Bettis DI;Johnson CA;Garvin MK;Sonka M;Abràmoff MD
一项初步研究表明，通过光学相干断层扫描（OCT）图像分析预测个体Humphrey 24-2视野（HVF 24-2）灵敏度阈值是可能的。我们评估了一种改进的方法以及其他3种预测算法对一组新的、完全独立的青光眼受试者的性能。受试者接受HVF 24-2和9场OCT（Heidelberg Spectralis）测试。共分割神经纤维（NFL）、神经节细胞和内丛状（GCL+IPL）层，并将其划分为52个与HVF 24-2测试位置匹配的扇区。Wilcoxon秩和检验用于检验四种预测模型的实际阈值和预测阈值之间的相关性R、均方根误差（RMSE）和一致性限（LoA）。训练数据包括来自我们的初步研究的111名青光眼患者的9场OCT和HVF 24-2阈值。我们研究了112例（112只眼）早期、中度或晚期原发性和继发性开角型青光眼患者。排除了扫描少于9次（15/112）或分割质量不足（11/97）的受试者。优化后的视网膜神经节细胞轴突复合体（RGC-AC）具有优越的上级平均R = 0.74（95%置信区间[CI]，0.67-0.76）和RMSE = 5.42（95% CI，5.1-5.7）dB，显著优于（P < 0.05/3）与其他三种模型相比：（R = 0.49; 95% CI，0.44-0.54; RMSE = 7.24 dB; 95% CI，6.6-7.8 dB），Garway-Heath（R = 0.66; 95% CI，0.60-0.68; RMSE = 6.07 dB; 95% CI，5.7-6.5 dB）和Donut（R = 0.67; 95% CI，0.61-0.69; RMSE = 6.08 dB，95% CI，5.8-6.4 dB）。基于9场OCT图像分析和RGC-AC概念提出的RGC-AC优化预测算法上级以前的方法，其性能接近HVF 24-2的再现性。
A pilot study showed that prediction of individual Humphrey 24-2 visual field (HVF 24-2) sensitivity thresholds from optical coherence tomography (OCT) image analysis is possible. We evaluate performance of an improved approach as well as 3 other predictive algorithms on a new, fully independent set of glaucoma subjects. Subjects underwent HVF 24-2 and 9-field OCT (Heidelberg Spectralis) testing. Nerve fiber (NFL), and ganglion cell and inner plexiform (GCL+IPL) layers were cosegmented and partitioned into 52 sectors matching HVF 24-2 test locations. The Wilcoxon rank sum test was applied to test correlation R, root mean square error (RMSE), and limits of agreement (LoA) between actual and predicted thresholds for four prediction models. The training data consisted of the 9-field OCT and HVF 24-2 thresholds of 111 glaucoma patients from our pilot study. We studied 112 subjects (112 eyes) with early, moderate, or advanced primary and secondary open angle glaucoma. Subjects with less than 9 scans (15/112) or insufficient quality segmentations (11/97) were excluded. Retinal ganglion cell axonal complex (RGC-AC) optimized had superior average R = 0.74 (95% confidence interval [CI], 0.67–0.76) and RMSE = 5.42 (95% CI, 5.1–5.7) dB, which was significantly better (P < 0.05/3) than the other three models: Naïve (R = 0.49; 95% CI, 0.44–0.54; RMSE = 7.24 dB; 95% CI, 6.6–7.8 dB), Garway-Heath (R = 0.66; 95% CI, 0.60–0.68; RMSE = 6.07 dB; 95% CI, 5.7–6.5 dB), and Donut (R = 0.67; 95% CI, 0.61–0.69; RMSE = 6.08 dB, 95% CI, 5.8–6.4 dB). The proposed RGC-AC optimized predictive algorithm based on 9-field OCT image analysis and the RGC-AC concept is superior to previous methods and its performance is close to the reproducibility of HVF 24-2.
登录
查看更多内容
影响因子：
3.7
作者：
Abràmoff MD;Wu X;Lee K;Tang L
通讯作者：
Tang L
影响因子：
4.4
作者：
Hood DC;Anderson SC;Wall M;Raza AS;Kardon RH
通讯作者：
Kardon RH
影响因子：
3.3
作者：
Giavarina D
通讯作者：
Giavarina D
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
4.4
作者：
Bogunovic, Hrvoje;Kwon, Young H.;Abramoff, Michael D.
通讯作者：
Abramoff, Michael D.