Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial.
Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial.
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有氧运动和饮食对患有非酒精性脂肪肝的糖尿病前期患者肝脏脂肪的影响：一项随机对照试验
DOI：
10.1038/s41598-017-16159-x
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发表时间：
2017-11-21
影响因子：
4.6
通讯作者：
Lu D
中科院分区：
文献类型：
--
作者：
Cheng S;Ge J;Zhao C;Le S;Yang Y;Ke D;Wu N;Tan X;Zhang X;Du X;Sun J;Wang R;Shi Y;Borra RJH;Parkkola R;Wiklund P;Lu D
该研究旨在评估有氧运动（AEx）训练和富含纤维的饮食是否可以降低患有非酒精性脂肪肝（NAFLD）的糖尿病前期患者的肝脂肪含量（HFC）并增强血糖控制。招募了来自中国上海市杨浦区七个诊所的 603 名患者。其中 115 名 50-65 岁的个体符合纳入标准（患有空腹血糖受损或糖耐量受损的 NAFLD），并被随机分配到运动组（AEx n = 29）、饮食组（饮食 n = 28）、运动加饮食组（AED n = 29）或不干预组（NI n = 29）。渐进式监督 AEx 训练（最大摄氧量 60-75% 强度）每周 2-3 次，每次 30-60 分钟，饮食干预为午餐，含 38% 碳水化合物和每天 12 克膳食纤维，持续 8.6 个月。 HFC 通过 1H MRS 进行评估。我们发现，干预后，AEx（−24.4％）、饮食（−23.2％）和AED（−47.9％）组中的HFC显着减少，而NI组则增加了20.9％（所有组的p = 0.001）。然而，与 NI 组（-0.6%）相比，只有 AED 组 HbA1c 显着降低（-4.4%，p = 0.01）。对于患有 NAFLD 的糖尿病前期患者来说，有氧运动训练与富含纤维的饮食相结合可以比单独运动或增加纤维摄入更有效地减少 HFC。
The study aimed to assess whether aerobic exercise (AEx) training and a fibre-enriched diet can reduce hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50–65-year fulfilled the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx n = 29), diet (Diet n = 28), exercise plus diet (AED n = 29), or no-intervention (NI n = 29) groups. Progressive supervised AEx training (60–75% VO2max intensity) was given 2-3 times/week in 30–60 min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet fibre of 12 g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was significantly reduced in the AEx (−24.4%), diet (−23.2%), and AED (−47.9%) groups by contrast to the 20.9% increase in the NI group (p = 0.001 for all) after intervention. However, only AED group significantly decreased HbA1c (−4.4%, p = 0.01) compared with the NI group (−0.6%). Aerobic exercise training combined with fibre-enriched diet can reduce HFC more effectively than either exercise or increased fibre-intake alone in pre-diabetic patients with NAFLD.
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影响因子：
8.2
作者：
Lindström, J;Peltonen, M;Tuomilehto, J
通讯作者：
Tuomilehto, J
影响因子：
9.8
作者：
Katsagoni, Christina N.;Georgoulis, Michael;Kontogianni, Meropi D.
通讯作者：
Kontogianni, Meropi D.
中国酒精性和非酒精性脂肪肝流行病学
影响因子：
4.1
作者：
Fan, Jian-Gao
通讯作者：
Fan, Jian-Gao
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
影响因子：
7.6
作者：
Angulo, P.
通讯作者：
Angulo, P.