Non-invasive temporal interference electrical stimulation of the human hippocampus.
Non-invasive temporal interference electrical stimulation of the human hippocampus.
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DOI：
10.1038/s41593-023-01456-8
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发表时间：
2023-11
影响因子：
25
通讯作者：
Grossman, Nir
中科院分区：
文献类型：
--
作者：
Violante, Ines R.;Alania, Ketevan;Cassara, Antonino M.;Neufeld, Esra;Acerbo, Emma;Carron, Romain;Williamson, Adam;Kurtin, Danielle L.;Rhodes, Edward;Hampshire, Adam;Kuster, Niels;Boyden, Edward S.;Pascual-Leone, Alvaro;Grossman, Nir
通过植入电极的脑深部刺激(DBS)在世界范围内被用于治疗严重的神经和精神疾病患者。然而，它的侵袭性阻碍了广泛的临床应用和研究部署。时间干扰(TI)是一种利用神经活动范围内不同频率的多个kHz电场实现非侵入性可操纵DBS的策略。在这里，我们报告了非侵入性DBS概念在人类中的验证。我们在人类身体上使用电场建模和测量来验证经颅TI刺激的轨迹可以在最小限度地暴露于覆盖的皮质的情况下在海马区定向聚焦。然后，我们使用功能磁共振成像和行为实验证明，TI刺激可以局部调节健康人的海马区活动，并提高对情节记忆的准确性。我们的结果展示了对人脑深层结构的定向、非侵入性电刺激。脑深部电刺激疗法受到将电极插入大脑的风险的限制。在这里，作者报告了使用khz电场的时间干扰在人的海马区进行非侵入性的脑深部刺激。
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain. Electrical deep brain stimulation therapy is limited by the risks of inserting electrodes into the brain. Here the authors report non-invasive deep brain stimulation in the human hippocampus using temporal interference of kHz electric fields.
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影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
5.7
作者：
Angenstein, Frank
通讯作者：
Angenstein, Frank
DOI：
10.1016/bs.plm.2017.03.006
发表时间：
2017-01-01
期刊：
PSYCHOLOGY OF LEARNING AND MOTIVATION, VOL 67
影响因子：
--
作者：
Finn, Bridgid
通讯作者：
Finn, Bridgid
影响因子：
5.3
作者：
Eldridge, LL;Engel, SA;Knowlton, BJ
通讯作者：
Knowlton, BJ