Effects of dietary manipulations and glucose infusion on glucagon response during exercise in rats.
Effects of dietary manipulations and glucose infusion on glucagon response during exercise in rats.
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饮食控制和葡萄糖输注对大鼠运动期间胰高血糖素反应的影响。
DOI：
10.1152/jappl.1997.83.1.148
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发表时间：
1997
影响因子：
3.3
通讯作者：
J. Lavoie
中科院分区：
文献类型：
--
作者：
M. Tadjore;R. Bergeron;M. Latour;F. Désy;C. Warren;J. Lavoie
本研究的目的是验证血糖浓度并不总是与运动中的胰高血糖素反应有关的假设。三组大鼠接受了长时间(3小时)的游泳运动。实验前一晚，两组大鼠的正常食物摄入量被限制了50%。这两组大鼠中的一组在整个运动过程中都被静脉注射葡萄糖以保持正常血糖。第三组大鼠在正常饮食条件下游泳。在没有输入葡萄糖的限食动物中，在运动75分钟、105分钟、150分钟和170分钟(从大约130 mg/dl到110 mg/dl)时，从动脉血中采集的血糖降低(P<；0.05)，而其他两组在运动期间测量到显著的升高(P<；0.05)。葡萄糖浓度曲线下的平均积分面积仅在美联储和两个限食组之间存在显著差异(P<；0.01)。在运动过程中，所有组的血浆胰岛素浓度下降(P<；0.05)，而血浆肾上腺素和去甲肾上腺素浓度在所有组显著升高(P<；0.01)。尽管在运动过程中不同组的血糖反应不同，尽管三组中至少有两组的运动血糖水平没有任何下降，但在运动期结束时，所有组的血浆胰高血糖素反应都有类似的增加(从大约250到550 pg/ml)。在饮食限制组，无论有没有葡萄糖输注，运动90min后胰高血糖素显著升高，但在喂食组仅在140min后才显著升高。这些结果表明，运动中的胰高血糖素反应并不总是与血糖的下降有关。
The purpose of the present investigation was to test the hypothesis that blood glucose concentration is not always related to glucagon response during exercise. Three groups of rats were submitted to a prolonged (3-h) swimming exercise. Two groups of rats had their normal food intake restricted by 50% the night before the experiment. One of these two groups of rats was intravenously infused with glucose throughout exercise to maintain euglycemia. The third group of rats swam while under normal dietary conditions. Plasma glucose, sampled in arterial blood, was reduced (P < 0.05) at 75, 105, 150, and 170 min of exercise (from approximately 130 to 110 mg/dl) in the food-restricted animals without glucose infusion, whereas a significant (P < 0.05) increase was measured in the two other groups during exercise. A significant (P < 0.01) difference in the mean integrated areas under the glucose-concentration curve was found only between the fed and the two food-restricted groups. Plasma insulin concentrations decreased (P < 0.05) similarly in all groups during exercise, whereas plasma epinephrine and norepinephrine concentrations increased significantly (P < 0.01) in all groups. Despite differences between groups in plasma glucose response during exercise, and despite the absence of any decrease in exercising blood glucose levels in at least two of the three groups, plasma glucagon responses were increased (P < 0.05) similarly in all groups (from approximately 250 to 550 pg/ml) at the end of the exercise period. The increase in glucagon was significant after 90 min of exercise in the food-restricted groups, with or without glucose infusion, but only after 140 min in the fed group. These results indicate that the glucagon response during exercise is not always linked to the decrease in plasma glucose.
运动期间的碳水化合物代谢：循环脂肪可用性的影响。
DOI：
10.1152/jappl.1995.79.2.506
发表时间：
1995
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Bracy,DP;Zinker,BA;Jacobs,JC;Lacy,DB;Wasserman,DH
通讯作者：
Wasserman,DH
运动引起的肝葡萄糖产生增加对葡萄糖供应和需求的敏感性。
DOI：
10.1152/ajpendo.1994.267.3.e411
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Berger,CM;Sharis,PJ;Bracy,DP;Lacy,DB;Wasserman,DH
通讯作者：
Wasserman,DH