Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans.
Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans.
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DOI：
10.1038/s41598-020-73942-z
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发表时间：
2020-10-09
影响因子：
4.6
通讯作者：
Turner J
中科院分区：
文献类型：
--
作者：
Ault RC;Headley CA;Hare AE;Carruthers BJ;Mejias A;Turner J
Tuberculosis (TB) is the leading cause of death due to a single infectious disease. Knowing when a person was infected with Mycobacterium tuberculosis (M.tb) is critical as recent infection is the strongest clinical risk factor for progression to TB disease in immunocompetent individuals. However, time since M.tb infection is challenging to determine in routine clinical practice. To define a biomarker for recent TB exposure, we determined whether gene expression patterns in blood RNA correlated with time since M.tb infection or exposure. First, we found RNA signatures that accurately discriminated early and late time periods after experimental infection in mice and cynomolgus macaques. Next, we found a 6-gene blood RNA signature that identified recently exposed individuals in two independent human cohorts, including adult household contacts of TB cases and adolescents who recently acquired M.tb infection. Our work supports the need for future longitudinal studies of recent TB contacts to determine whether biomarkers of recent infection can provide prognostic information of TB disease risk in individuals and help map recent transmission in communities.
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影响因子：
82.9
作者：
Esmail, Hanif;Lai, Rachel P.;Lesosky, Maia;Wilkinson, Katalin A.;Graham, Christine M.;Coussens, Anna K.;Oni, Tolu;Warwick, James M.;Said-Hartley, Qonita;Koegelenberg, Coenraad F.;Walzl, Gerhard;Flynn, JoAnne L.;Young, Douglas B.;Barry, Clifton E., III;O'Garra, Anne;Wilkinson, Robert J.
通讯作者：
Wilkinson, Robert J.
DOI：
10.1093/infdis/jix311
发表时间：
2017-11-03
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Shah NS;Kim P;Kana BD;Rustomjee R
通讯作者：
Rustomjee R
DOI：
10.1093/infdis/jix362
发表时间：
2017-11-03
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Churchyard G;Kim P;Shah NS;Rustomjee R;Gandhi N;Mathema B;Dowdy D;Kasmar A;Cardenas V
通讯作者：
Cardenas V
影响因子：
--
作者：
GEDDEDAHL, T
通讯作者：
GEDDEDAHL, T
影响因子：
3.1
作者：
Coleman, M. Teresa;Maiello, Pauline;Lin, Philana Ling
通讯作者：
Lin, Philana Ling