fNIRS for Tracking Brain Development in the Context of Global Health Projects.

fNIRS for Tracking Brain Development in the Context of Global Health Projects.
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在全球卫生项目的背景下跟踪大脑发育的FNIRS。

DOI:
10.3390/photonics6030089
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发表时间:
2019-08-02
期刊:
影响因子:
2.4
通讯作者:
Elwell CE
Elwell CE
中科院分区:
物理与天体物理3区
文献类型:
--
作者:
Blasi A;Lloyd-Fox S;Katus L;Elwell CE

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在过去的 25 年里,功能性近红外光谱 (fNIRS) 已成为研究大脑功能的宝贵工具,并且可以说,它在年轻参与者中发现了最成功的应用。由于其对婴儿友好的特点,该技术有助于我们理解感官知觉和社会认知技能的神经基础,从而帮助塑造神经认知发展领域的研究。此外,它还为探索大脑发育受损的标志物提供了途径。 fNIRS 仪器和方法的进步使其应用进一步发展,包括研究复杂且相互作用的社会经济和环境逆境对大脑发育的影响。为此,有必要将 fNIRS 从资源丰富的研究实验室(大多数位于高收入国家)中撤出,以研究低收入和中等收入国家 (LMIC) 资源匮乏环境中的高危人群。在这里,我们回顾了该技术在全球健康研究中的使用,讨论了 fNIRS 研究在中低收入国家的实施,特别强调全球健康脑成像 (BRIGHT) 项目,并考虑了其在这一新兴领域的潜力。
Over the past 25 years, functional near-infrared spectroscopy (fNIRS) has emerged as a valuable tool to study brain function, and it is in younger participants where it has found, arguably, its most successful application. Thanks to its infant-friendly features, the technology has helped shape research in the neurocognitive development field by contributing to our understanding of the neural underpinnings of sensory perception and socio-cognitive skills. Furthermore, it has provided avenues of exploration for markers of compromised brain development. Advances in fNIRS instrumentation and methods have enabled the next step in the evolution of its applications including the investigation of the effects of complex and interacting socio-economic and environmental adversities on brain development. To do this, it is necessary to take fNIRS out of well-resourced research labs (the majority located in high-income countries) to study at-risk populations in resource-poor settings in low- and middle-income countries (LMICs). Here we review the use of this technology in global health studies, we discuss the implementation of fNIRS studies in LMICs with a particular emphasis on the Brain Imaging for Global Health (BRIGHT) project, and we consider its potential in this emerging field.
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