Diarrhoeal Disease
Diarrhoeal Disease
复制标题
腹泻病
作者：
C A Hart;L W Umar
“主要是轮状病毒和另一种肠道病原体！5调查是在雨季进行的，那时卡耶坦线虫占主导地位，病毒最少发现：没有：没有被描述。渗透成分首先是刷状缘二糖酶(乳糖酶、蔗糖酶和麦芽糖酶)合成减少，随后绒毛肠细胞死亡，导致绒毛变平。营养良好的儿童腹泻平均持续6天，但有些可能持续更长时间。没有证据表明牛奶和固体物质应该被扣留，尽管失去了二糖酶的活性。我们都可能在一生中定期感染轮状病毒，但只有在最初的几次感染才会导致疾病，除非出现全新的轮状病毒株。墨西哥的一项队列研究表明，儿童感染一次轮状病毒后，有62%的几率发生后续感染，23%发生腹泻，两次和三次发作后的几率分别为40%和17%，34%和8%。经过多年的研发，已生产出与发达国家5，10一样有效的猴重组轮状病毒活疫苗。这种疫苗包含四个最重要的中和表位(称为G1、G2、G3、G4)，并已在美国获得使用许可。尽管这无疑是向前迈出的一大步，但还有
"Predominantly rotavirus plus another enteropathogen !5urvey done during the wet seasonwhen C. cayetanensis predominates and virusesare least often found NO:Not sought be described. The osmotic component results from, first, a decreased synthesis of the brush border disaccharidase enzymes (lactase, sucrase and maltase), and subsequently death of the villous enterocytes leading to flattening of the villi. The diarrhoea in well-nourished children persists for an average of 6 days but in some may persist much longer. There is no evidence to suggest that milk and solids should be withheld, despite the loss of dissaccharidase activity. It is probable that we are all infected with rotavirus at regular intervals throughout our lifetimes but that it is only on the first few occasions that infection results in disease, unless an entirely new rotavirus strain intervenes', A cohort study in Mexico has demonstrated that after one rotavirus infection a child has a 62% chance of developing a subsequent infection and 23% chance of developing diarrhoea, after two and three attacks the chances were 40% and 17%, and 34% and 8%, respectively', After many years of development a live simian reassortant rotavirus vaccine has been produced which has been shown to be as effective in developing as developed countries5,1O, l l . This vaccine incorporates the four most important neutralizing epitopes (called G I, G2, G3, G4), and has been licensed for use in the USA. Although this is undoubtedly a big step forward, there are
DOI：
10.1073/pnas.90.11.5267
发表时间：
1993-06-01
影响因子：
11.1
作者：
TRUCKSIS, M;GALEN, JE;KAPER, JB
通讯作者：
KAPER, JB
DOI：
10.1073/pnas.88.12.5242
发表时间：
1991-06-01
影响因子：
11.1
作者：
FASANO, A;BAUDRY, B;KAPER, JB
通讯作者：
KAPER, JB