Galectin-1 research in T cell immunity: past, present and future.
Galectin-1 research in T cell immunity: past, present and future.
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DOI：
10.1016/j.clim.2011.09.011
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Dimitroff CJ
中科院分区：
文献类型：
--
作者：
Cedeno-Laurent F;Dimitroff CJ
Galectin-1 (Gal-1) is one of 15 evolutionarily conserved β-galactoside-binding proteins that display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is variably expressed on immune cells and endothelial cells, though is commonly found and secreted at high levels in cancer cells. It induces apoptosis in effector T cells through homodimeric binding of N-acetyllactosamines on membrane glycoproteins (Gal-1 ligands). There is also compelling evidence in models of cancer and autoimmunity that recombinant Gal-1 (rGal-1) can potentiate immunoregulatory function of T cells. Here, we review Gal-1’s structural and functional features, while analyzing potential drawbacks and technical difficulties inherent to rGal-1’s nature. We also describe new Gal-1 preparations that exhibit dimeric stability and functional activity on T cells, providing renewed excitement for studying Gal-1 efficacy and/or use as anti-inflammatory therapeutics. We lastly summarize strategies targeting the Gal-1 – Gal-1 ligand axis to circumvent Gal-1-driven immune escape in cancer and boost anti-tumor immunity.
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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