Iron-Loaded Magnetic Nanocapsules for pH-Triggered Drug Release and MRI Imaging.
Iron-Loaded Magnetic Nanocapsules for pH-Triggered Drug Release and MRI Imaging.
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DOI：
10.1021/cm404168a
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发表时间：
2014-03-25
影响因子：
8.6
通讯作者：
Anker, Jeffrey N.
中科院分区：
文献类型：
--
作者：
Chen, Hongyu;Sulejmanovic, Dino;Moore, Thomas;Colvin, Daniel C.;Qi, Bin;Mefford, O. Thompson;Gore, John C.;Alexis, Frank;Hwu, Shiou-Jyh;Anker, Jeffrey N.
制备了磁性纳米胶囊，用于控制药物释放、磁辅助给药和MRI成像。这些磁性纳米胶囊由稳定的铁纳米核和介孔二氧化硅壳组成，通过控制椭球状赤铁矿在二氧化硅中的包封，在酸中部分蚀刻赤铁矿核，并用氢还原核合成。铁芯提供了高饱和磁化强度，在空气中至少6个月，在水溶液中至少1个月的抗氧化稳定性。铁核和介孔二氧化硅壳之间的中空空间被用来装载抗癌药物和t1加权MRI造影剂（Gd-DTPA）。这些多功能单分散磁性“纳米眼”被生物相容性聚赖氨酸和海藻酸钠的多聚电解质层包裹，以控制药物释放作为ph的函数。我们研究了磁性纳米眼的ph控制释放、磁滞曲线和T1/T2 MRI对比。同时作为MRI造影剂，其松弛度分别为8.6 mM-1 s-1 （r1）和285 mM-1 s-1 （r2）。
Magnetic nanocapsules were synthesized for controlled drug release, magnetically assisted delivery, and MRI imaging. These magnetic nanocapsules, consisting of a stable iron nanocore and a mesoporous silica shell, were synthesized by controlled encapsulation of ellipsoidal hematite in silica, partial etching of the hematite core in acid, and reduction of the core by hydrogen. The iron core provided a high saturation magnetization and was stable against oxidation for at least 6 months in air and 1 month in aqueous solution. The hollow space between the iron core and mesoporous silica shell was used to load anticancer drug and a T1-weighted MRI contrast agent (Gd-DTPA). These multifunctional monodispersed magnetic “nanoeyes” were coated by multiple polyelectrolyte layers of biocompatible poly-l-lysine and sodium alginate to control the drug release as a function of pH. We studied pH-controlled release, magnetic hysteresis curves, and T1/T2 MRI contrast of the magnetic nanoeyes. They also served as MRI contrast agents with relaxivities of 8.6 mM–1 s–1 (r1) and 285 mM–1 s–1 (r2).
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
影响因子：
13.3
作者：
Hacliipanayis, Coslas G.;Bonder, Michael J.;Balakrishanan, Srinivasan;Wang, Xiaoxia;Mao, Huio;Hadjipanayis, George C.
通讯作者：
Hadjipanayis, George C.
影响因子：
3.9
作者：
Hu, Shang-Hsiu;Tsai, Chia-Hui;Chen, San-Yuan
通讯作者：
Chen, San-Yuan
作为药物载体的磁性、上转换发光和介孔核壳结构纳米复合材料的合成
影响因子：
19
作者：
Gai, Shili;Yang, Piaoping;Lin, Jun
通讯作者：
Lin, Jun
影响因子：
3.1
作者：
Johannsen, M;Gneveckow, U;Jordan, A
通讯作者：
Jordan, A