The paf gene product modulates asexual development in Penicillium chrysogenum.
The paf gene product modulates asexual development in Penicillium chrysogenum.
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DOI:
10.1002/jobm.201000321
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发表时间:
2011-06
影响因子:
3.1
通讯作者:
Marx, Florentine
中科院分区:
文献类型:
--
作者:
Hegedues, Nikoletta;Sigl, Claudia;Zadra, Ivo;Pocsi, Istvan;Marx, Florentine
Penicillium chrysogenum secretes a low molecular weight, cationic and cysteine-rich protein (PAF). It has growth inhibitory activity against the model organism Aspergillus nidulans and numerous zoo- and phytopathogenic fungi but shows only minimal conditional antifungal activity against the producing organism itself. In this study we provide evidence for an additional function of PAF which is distinct from the antifungal activity against putative ecologically concurrent microorganisms. Our data indicate that PAF enhances conidiation in P. chrysogenum by modulating the expression of brlA, the central regulatory gene for mitospore development. A paf deletion strain showed a significant impairment of mitospore formation which sustains our hypothesis that PAF plays an important role in balancing asexual differentiation in P. chrysogenum.
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DOI:
10.1111/j.1742-4658.2009.07011.x
发表时间:
2009-05
期刊:
The FEBS journal
影响因子:
--
作者:
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DOI:
10.1038/nbt0587-494
发表时间:
1987-05-01
期刊:
BIO-TECHNOLOGY
影响因子:
--
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通讯作者:
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影响因子:
3.1
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通讯作者:
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DOI:
10.1007/s10482-008-9263-x
发表时间:
2008-10-01
影响因子:
2.6
作者:
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Vagvolgyi, Csaba