Molecular mechanisms of exercise contributing to tissue regeneration.
Molecular mechanisms of exercise contributing to tissue regeneration.
复制标题
运动促进组织再生的分子机制
DOI：
10.1038/s41392-022-01233-2
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发表时间：
2022-11-30
影响因子：
39.3
通讯作者：
Cheng, Lin
中科院分区：
文献类型：
--
作者：
Chen, Jibao;Zhou, Ren;Feng, Ye;Cheng, Lin
几个世纪以来，体力活动一直被认为是促进人类健康的基本要素。因此，运动干预被鼓励与久坐的生活方式作斗争。分子生物学的最新进展表明，耐力运动和抗阻运动训练这两种传统的运动类型都会触发一系列的生理反应，从而解开运动对人体的调节机制。因此，运动被认为是缓解一系列疾病的候选方法，如代谢性疾病、神经退行性疾病、肿瘤和心血管疾病。尤其是近几十年来，运动促进组织再生的能力引起了许多研究人员的关注。由于大多数成人人体器官的再生能力较弱，提高组织再生效率是目前再生医学面临的关键挑战。随着研究的深入，运动诱导的组织再生似乎为对抗损伤或衰老提供了一种新的方法，为越来越多的“运动模拟”奠定了坚实的理论基础。这些药物正成为那些无法体验锻炼好处的人的药物替代品。在这里，我们全面介绍运动对不同器官组织再生的益处，主要集中在肌肉骨骼系统、心血管系统和神经系统。我们还讨论了与运动的再生效应和新兴的治疗运动模拟再生相关的潜在分子机制，以及相关的机会和挑战。我们的目标是描述与运动诱导的组织再生相关的不同生理机制在不同器官上的当前进展，并促进模拟运动益处的药物的开发。
Physical activity has been known as an essential element to promote human health for centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle. Recent rapid advances in molecular biotechnology have demonstrated that both endurance and resistance exercise training, two traditional types of exercise, trigger a series of physiological responses, unraveling the mechanisms of exercise regulating on the human body. Therefore, exercise has been expected as a candidate approach of alleviating a wide range of diseases, such as metabolic diseases, neurodegenerative disorders, tumors, and cardiovascular diseases. In particular, the capacity of exercise to promote tissue regeneration has attracted the attention of many researchers in recent decades. Since most adult human organs have a weak regenerative capacity, it is currently a key challenge in regenerative medicine to improve the efficiency of tissue regeneration. As research progresses, exercise-induced tissue regeneration seems to provide a novel approach for fighting against injury or senescence, establishing strong theoretical basis for more and more “exercise mimetics.” These drugs are acting as the pharmaceutical alternatives of those individuals who cannot experience the benefits of exercise. Here, we comprehensively provide a description of the benefits of exercise on tissue regeneration in diverse organs, mainly focusing on musculoskeletal system, cardiovascular system, and nervous system. We also discuss the underlying molecular mechanisms associated with the regenerative effects of exercise and emerging therapeutic exercise mimetics for regeneration, as well as the associated opportunities and challenges. We aim to describe an integrated perspective on the current advances of distinct physiological mechanisms associated with exercise-induced tissue regeneration on various organs and facilitate the development of drugs that mimics the benefits of exercise.
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影响因子：
8.2
作者：
Allet, L.;Armand, S.;de Bie, R. A.;Golay, A.;Monnin, D.;Aminian, K.;Staal, J. B.;de Bruin, E. D.
通讯作者：
de Bruin, E. D.
DOI：
10.1515/med-2017-0022
发表时间：
2017
期刊：
Open medicine (Warsaw, Poland)
影响因子：
--
作者：
Ceccarelli G;Benedetti L;Arcari ML;Carubbi C;Galli D
通讯作者：
Galli D
影响因子：
8
作者：
Bezzerides, Vassilios J.;Platt, Colin;Rosenzweig, Anthony
通讯作者：
Rosenzweig, Anthony
影响因子：
9.2
作者：
Arthur ST;Cooley ID
通讯作者：
Cooley ID
影响因子：
8.9
作者：
Baraldo, Martina;Geremia, Alessia;Blaauw, Bert
通讯作者：
Blaauw, Bert