Muscle Stem Cell and Physical Activity: What Point is the Debate at?
Muscle Stem Cell and Physical Activity: What Point is the Debate at?
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DOI：
10.1515/med-2017-0022
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Galli D
中科院分区：
文献类型：
--
作者：
Ceccarelli G;Benedetti L;Arcari ML;Carubbi C;Galli D
在过去的15年里，人们发现，定期进行体育活动可以降低许多疾病（心血管疾病，糖尿病等）的风险。它是控制体重和能量消耗的基础，以对抗肥胖。不同的研究小组提出了许多分子机制，负责身体活动在健康生活中的积极影响。然而，许多问题仍有待澄清。在这篇简短的综述中，我们报道了体育锻炼对健康骨骼肌和心肌影响的最新观察结果，重点是肌肉干细胞。最后一个代表了损伤后肌肉再生的基本要素，也是健康肌肉稳态的基本要素。有趣的是，在这两种肌肉组织中，身体活动的形态学后果是生理性肥大，这取决于分化细胞和干细胞中的不同现象。身体锻炼效应的信号传导途径在骨骼肌和心肌中存在共同的元素，如特定转录因子、增殖途径和细胞因子的激活。最近，已经证明了翻译后（miRNA）或表观遗传（DNA甲基化）修饰。然而，有几点仍然没有解决，因此需要对运动对肌肉干细胞的影响进行新的研究。
In the last 15 years, it emerged that the practice of regular physical activity reduces the risks of many diseases (cardiovascular diseases, diabetes, etc.) and it is fundamental in weight control and energy consuming to contrast obesity. Different groups proposed many molecular mechanisms as responsible for the positive effects of physical activity in healthy life. However, many points remain to be clarified. In this mini-review we reported the latest observations on the effects of physical exercise on healthy skeletal and cardiac muscle focusing on muscle stem cells. The last ones represent the fundamental elements for muscle regeneration post injury, but also for healthy muscle homeostasis. Interestingly, in both muscle tissues the morphological consequence of physical activity is a physiological hypertrophy that depends on different phenomena both in differentiated cells and stem cells. The signaling pathways for physical exercise effects present common elements in skeletal and cardiac muscle, like activation of specific transcription factors, proliferative pathways, and cytokines. More recently, post translational (miRNAs) or epigenetic (DNA methylation) modifications have been demonstrated. However, several points remain unresolved thus requiring new research on the effect of exercise on muscle stem cells.
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DOI：
10.1111/apha.12532
发表时间：
2016-01
期刊：
Acta physiologica (Oxford, England)
影响因子：
--
作者：
Brook MS;Wilkinson DJ;Phillips BE;Perez-Schindler J;Philp A;Smith K;Atherton PJ
通讯作者：
Atherton PJ
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
影响因子：
5.5
作者：
Baggish, Aaron L.;Hale, Andrew;Chan, Stephen Y.
通讯作者：
Chan, Stephen Y.
影响因子：
64.8
作者：
Eulalio, Ana;Mano, Miguel;Giacca, Mauro
通讯作者：
Giacca, Mauro
影响因子：
2.1
作者：
Farup, Jean;Sorensen, Henrik;Kjolhede, Tue
通讯作者：
Kjolhede, Tue