Sickle cell disease incidence among newborns in New York State by maternal race/ethnicity and nativity.
Sickle cell disease incidence among newborns in New York State by maternal race/ethnicity and nativity.
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DOI：
10.1038/gim.2012.128
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发表时间：
2013-03
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影响因子：
--
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中科院分区：
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据估计，镰状细胞病在非洲裔美国人出生时的发病率为1:300-400，在非洲和加勒比移民中发病率较高，在西班牙裔美国人出生中发病率较低。本研究确定了纽约州新生儿中按母亲种族/民族和出生地分层的镰状细胞病发病率。纽约州居民所生的确诊镰状细胞病新生儿由2000-2008年纽约州新生儿筛查项目确定，并与出生记录相匹配，以获得出生和孕产妇信息。计算年发病率，并进行双变量分析，以检查与母亲种族/民族和出生的关系。从2000年到2008年，纽约州有1911名新生儿被诊断患有镰状细胞病，并与出生证明文件相匹配。每1 146名活产婴儿中就有1人被诊断患有镰状细胞病。非西班牙裔黑人母亲的新生儿占镰状细胞病病例的86%，而西班牙裔母亲的新生儿占12%。据估计，非西班牙裔黑人母亲的活产率为1:20 30，西班牙裔母亲的活产率为1:23 320，非西班牙裔白人母亲的活产率为1:41 647。在国外出生的非西班牙裔黑人母亲的新生儿镰状细胞病的发病率比在美国出生的非西班牙裔黑人母亲所生的新生儿高两倍（P < 0.001）。这项研究提供了第一个美国估计镰状细胞病发病率的母亲出生。在美国以外出生的妇女占纽约州出生的镰状细胞病儿童的大多数。这些调查结果确定了高危人群，并为促进对受影响儿童进行持续高质量医疗管理的外联活动提供了信息。
Sickle cell disease is estimated to occur in 1:300–400 African-American births, with higher rates among immigrants from Africa and the Caribbean, and is less common among Hispanic births. This study determined sickle cell disease incidence among New York State newborns stratified by maternal race/ethnicity and nativity. Newborns with confirmed sickle cell disease born to New York State residents were identified by the New York State newborn screening program for the years 2000–2008 and matched to birth records to obtain birth and maternal information. Annual incidence rates were computed and bivariate analyses were conducted to examine associations with maternal race/ethnicity and nativity. From 2000 to 2008, 1,911 New York State newborns were diagnosed with sickle cell disease and matched to the birth certificate files. One in every 1,146 live births was diagnosed with sickle cell disease. Newborns of non-Hispanic black mothers accounted for 86% of sickle cell disease cases whereas newborns of Hispanic mothers accounted for 12% of cases. The estimated incidence was 1:230 live births for non-Hispanic black mothers, 1:2,320 births for Hispanic mothers, and 1:41,647 births for non-Hispanic white mothers. Newborns of foreign-born non-Hispanic black mothers had a twofold higher incidence of sickle cell disease than those born to US-born non-Hispanic black mothers (P < 0.001). This study provides the first US estimates of sickle cell disease incidence by maternal nativity. Women born outside the United States account for the majority of children with sickle cell disease born in New York State. Such findings identify at-risk populations and inform outreach activities that promote ongoing, high-quality medical management to affected children.
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影响因子：
2.3
作者：
Korzeniewski, S. J.;Grigorescu, V.;Young, W. I.
通讯作者：
Young, W. I.
影响因子：
5.1
作者：
Lerner, Norma B.;Platania, Bridget L.;LaBella, Sandra
通讯作者：
LaBella, Sandra
DOI：
10.1007/s11524-011-9618-x
发表时间：
2012-02-01
影响因子：
6.6
作者：
Siddiqui, Saira;Schunk, Kelly;Green, Nancy S.
通讯作者：
Green, Nancy S.
影响因子：
5
作者：
Pacheco AG;Saraceni V;Tuboi SH;Moulton LH;Chaisson RE;Cavalcante SC;Durovni B;Faulhaber JC;Golub JE;King B;Schechter M;Harrison LH
通讯作者：
Harrison LH
影响因子：
20.3
作者：
Kreuels, Benno;Kreuzberg, Christina;May, Juergen
通讯作者：
May, Juergen