Functional connectivity of hippocampal networks in temporal lobe epilepsy.
Functional connectivity of hippocampal networks in temporal lobe epilepsy.
复制标题
颞叶癫痫中海马网络的功能连通性。
作者：
Haneef Z;Lenartowicz A;Yeh HJ;Levin HS;Engel J Jr;Stern JM
由于海马体和其他颞叶结构的连接，颞叶癫痫(TLE)会影响到颞叶以外的脑区。利用功能连接性MRI，我们确定了TLE患者海马区网络的变化，以评估异常的更完整的分布。在左侧TLE组(n=13)、右侧TLE组(n=11)和健康对照组(n=16)的右侧和左侧海马区确定感兴趣区(ROI)。通过关联静息状态下的低频fMRI血氧水平依赖(BOLD)信号波动，确定与这些ROI功能相关的脑区。分组结果比较采用独立样本t检验。TLE与涉及边缘网络几个关键区域(颞叶、脑岛、丘脑)、额叶、角回、基底节、脑干和小脑的海马连接性增加有关，而涉及感觉运动皮质(视觉、躯体感觉、听觉、初级运动)和默认模式网络(楔前)的连接性降低。左侧TLE较右侧TLE有更明显的连接性改变。在TLE中观察到的连接性变化表明，在TLE中广泛参与大脑的网络功能障碍。左侧和右侧TLE之间的海马区连接性有明显差异。
Temporal Lobe Epilepsy (TLE) affects brain areas beyond the temporal lobes due to connections of the hippocampi and other temporal lobe structures. Using functional connectivity MRI, we determined the changes of hippocampal networks in TLE to assess for a more complete distribution of abnormality. Regions of interest (ROIs) were defined in the right and left hippocampi in three groups of participants- left TLE (n=13), right TLE (n=11) and healthy controls (n=16). Brain regions functionally connected to these ROIs were identified by correlating resting-state low-frequency fMRI Blood Oxygenation Level Dependent (BOLD) signal fluctuations. The grouped results were compared using independent sample t-test. TLE was associated with increased hippocampal connectivity involving several key areas of the limbic network (temporal lobe, insula, thalamus), frontal lobes, angular gyrus, basal ganglia, brainstem and cerebellum along with reduced connectivity involving areas of the sensorimotor cortex (visual, somatosensory, auditory, primary motor) and the default mode network (precuneus). Left TLE had more marked connectivity changes than right TLE. The observed connectivity changes in TLE indicate dysfunctional networks that underlie widespread brain involvement in TLE. There are identifiable differences in the connectivity of the hippocampi between left and right TLE.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
6
作者：
Frings, Lars;Schulze-Bonhage, Andreas;Wagner, Kathrin
通讯作者：
Wagner, Kathrin
影响因子：
2.6
作者：
Giovagnoli, AR
通讯作者：
Giovagnoli, AR
影响因子：
3.7
作者：
Blumenfeld, H;McNally, KA;Spencer, SS
通讯作者：
Spencer, SS