Urinary concentrations of parabens mixture and pregnancy glucose levels among women from a fertility clinic.
Urinary concentrations of parabens mixture and pregnancy glucose levels among women from a fertility clinic.
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DOI：
10.1016/j.envres.2018.10.009
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发表时间：
2019-01
影响因子：
8.3
通讯作者：
EARTH Study Team
中科院分区：
文献类型：
--
作者：
Bellavia A;Chiu YH;Brown FM;Mínguez-Alarcón L;Ford JB;Keller M;Petrozza J;Williams PL;Ye X;Calafat AM;Hauser R;James-Todd T;EARTH Study Team
许多内分泌干扰物质（EDC）与妊娠糖尿病（GDM）的危险因素有关。然而，没有人类研究调查妊娠暴露于对羟基苯甲酸酯（一类EDCs）与妊娠血糖水平（GDM的一个危险因素）之间的关系。此外，对于低生育能力女性（GDM的高风险群体）的这种关联知之甚少。来自环境和生殖健康研究的241名妇女在妊娠1和/或2个月的尿液中对羟基苯甲酸甲酯、对羟基苯甲酸丙酯和对羟基苯甲酸丁酯的浓度，以及在妊娠2个月后期进行的非空腹50克葡萄糖负荷试验（GLT）后的血糖水平。利用对羟基苯甲酸甲酯、对羟基苯甲酸丁酯和对羟基苯甲酸丙酯的比重调整后的妊娠血糖水平与妊娠期平均血糖水平之间的相关性，在线性回归模型中进行了评估，使用每种对羟基苯甲酸酯分布的四分位数，并作为对羟基苯甲酸酯混合物，使用相互调整和贝叶斯核机回归（BKMR），这是一种最近提出的研究化学混合物的方法，可以灵活地模拟化学物质的联合效应。当时对对羟基苯甲酸酯1的调查没有提供任何显著的结果。当使用多元回归和BKMR研究对羟基苯甲酸酯作为化学混合物时，我们观察到对羟基苯甲酸丁酯（例如比较第4和第1四分位数）与妊娠早期（校正差值=12.5 mg/dL; 95% CI: 0.9, 24.2）和妊娠中期（校正差值=11.2 mg/dL; 95% CI: 0.2, 22.3）与葡萄糖水平呈正相关，而妊娠早期对羟基苯甲酸丙酯与葡萄糖水平呈负相关（校正差值= - 22.3 mg/dL; 95% CI: - 43.2, - 1.4）。我们发现妊娠早期对羟基苯甲酸丁酯和对羟基苯甲酸丙酯尿浓度与GDM高风险妇女的血糖水平相关，即使在调整了潜在的混杂因素后也是如此。由于对羟基苯甲酸酯的接触很普遍，这些发现可能建议进一步调查这类化学物质对妊娠健康的影响。
A number of endocrine disrupting chemicals (EDC) have been associated with gestational diabetes (GDM) risk factors. However, no human study has investigated the association between pregnancy exposure to parabens, a class of EDCs, and pregnancy glucose levels, a risk factor for GDM. Furthermore, little is known about this association in subfertile women—a group at high risk of GDM. A total of 241 women from the Environment and Reproductive Health Study had data available on 1st and/or 2nd trimester urinary methylparaben, propylparaben, and butylparaben concentrations, and blood glucose levels after the glucose loading test (GLT), a non-fasting 50 gram glucose loading test taken at late 2nd trimester. Trimester-specific associations between specific gravity adjusted methylparaben, butylparaben, and propylparaben with adjusted mean of pregnancy glucose levels were evaluated in linear regression models, using quartiles of each paraben’s distribution, and as a paraben mixture, using mutual adjustment and Bayesian kernel machine regression (BKMR), a recently proposed method for investigating chemical mixtures that flexibly models the joint effect of chemicals. Investigating parabens one at the time did not provide any significant results. When investigating parabens as a chemical mixture with both multiple regression and BKMR, we observed positive associations of butylparaben (e.g comparing the 4th and 1st quartiles) with glucose levels, for both the 1st trimester (adjusted difference=12.5 mg/dL; 95% CI: 0.9, 24.2) and 2nd trimester (adjusted difference=11.2 mg/dL; 95% CI: 0.2, 22.3), and a negative association between 1st trimester propylparaben and glucose (adjusted difference=−22.3 mg/dL; 95% CI: −43.2, −1.4). We found 1st trimester butylparaben and propylparaben urinary concentrations to be associated with glucose levels in a pregnancy cohort of women at high risk of GDM, even after adjusting for potential confounders. Because exposure to parabens is widespread, these findings may suggest further investigating the effects of this chemical class on pregnancy health.
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影响因子：
8.3
作者：
Aker, Amira M.;Watkins, Deborah J.;Johns, Lauren E.;Ferguson, Kelly K.;Soldin, Offie P.;Del Toro, Liza V. Anzalota;Alshawabkeh, Akram N.;Cordero, Jose F.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
7.2
作者：
Caughey, Aaron B.
通讯作者：
Caughey, Aaron B.
DOI：
10.1016/j.reprotox.2015.02.002
发表时间：
2015-04
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Dodge LE;Kelley KE;Williams PL;Williams MA;Hernández-Díaz S;Missmer SA;Hauser R
通讯作者：
Hauser R
影响因子：
2
作者：
Ehrlich, Shelley;Lambers, Donna;Ho, Shuk-Mei
通讯作者：
Ho, Shuk-Mei
影响因子：
11.8
作者：
James-Todd TM;Meeker JD;Huang T;Hauser R;Ferguson KK;Rich-Edwards JW;McElrath TF;Seely EW
通讯作者：
Seely EW