Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women.
Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women.
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DOI：
10.1016/j.envres.2016.07.002
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发表时间：
2016-11
影响因子：
8.3
通讯作者：
Meeker, John D.
中科院分区：
文献类型：
--
作者：
Aker, Amira M.;Watkins, Deborah J.;Johns, Lauren E.;Ferguson, Kelly K.;Soldin, Offie P.;Del Toro, Liza V. Anzalota;Alshawabkeh, Akram N.;Cordero, Jose F.;Meeker, John D.
苯酚和对羟基苯甲酸酯是普遍存在的环境污染物。来自动物研究和有限的人类数据的证据表明，它们可能是内分泌干扰物。在目前的研究中，我们研究了106名孕妇的酚类和对羟基苯甲酸酯与生殖激素和甲状腺激素的关系，这些孕妇被招募参加前瞻性队列，“波多黎各探索污染威胁试验场"。尿液暴露生物标志物（双酚A、三氯生、二苯甲酮-3，2，4-二氯苯酚、2，5-二氯苯酚、对羟基苯甲酸丁酯、甲酯和丙酯）和血清激素水平（雌二醇、孕酮、性激素结合球蛋白（SHBG）、游离三碘甲状腺原氨酸（FT 3），游离甲状腺素（FT 4）和促甲状腺激素）在妊娠期间的两个时间点（16-20周和24-28周）进行测量。我们使用线性混合模型来评估整个妊娠期间暴露生物标志物和激素水平之间的关系，控制尿比重，母亲年龄，BMI和教育。在敏感性分析中，我们使用线性回归评估了暴露与激素水平之间的横截面关系，这些激素水平按研究访视分层。尼泊金甲酯的IQR增加与SHBG增加7.70%（95%CI 1.50，13.90）相关。此外，尼泊金丁酯的IQR增加与雌二醇降低8.46%（95% CI 16.92，0.00）以及雌二醇/孕酮降低9.34%（95% CI −18.31，−0.38）相关。相反，尼泊金丁酯的IQR增加与FT 4增加5.64%（95% CI 1.26，10.02）相关。预后一直与酚类呈负相关，但没有达到统计学意义。分层后，尼泊金甲酯和尼泊金丙酯在第一时间点（16-20周）与雌二醇呈负相关，在第二时间点（24-28周）与雌二醇呈正相关。在这个正在进行的出生队列中，某些酚类和对羟基苯甲酸酯与怀孕期间生殖和甲状腺激素水平的改变有关。这些变化可能会对母亲或其后代的健康产生不利影响，但需要进行更多的研究。
Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, “Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)”. Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16–20 weeks and 24–28 weeks). We used linear mixed models to assess relationships between exposure biomarkers and hormone levels across pregnancy, controlling for urinary specific gravity, maternal age, BMI and education. In sensitivity analyses, we evaluated cross-sectional relationships between exposure and hormone levels stratified by study visit using linear regression. An IQR increase in methyl paraben was associated with a 7.70% increase (95% CI 1.50, 13.90) in SHBG. Furthermore, an IQR increase in butyl paraben as associated with an 8.46% decrease (95% CI 16.92, 0.00) in estradiol, as well as a 9.34% decrease (95% CI −18.31, −0.38) in estradiol/progesterone. Conversely, an IQR increase in butyl paraben was associated with a 5.64% increase (95% CI 1.26, 10.02) in FT4. Progesterone was consistently negatively associated with phenols, but none reached statistical significance. After stratification, methyl and propyl paraben were suggestively negatively associated with estradiol at the first time point (16–20 weeks), and suggestively positively associated with estradiol at the second time point (24–28 weeks). Within this ongoing birth cohort, certain phenols and parabens were associated with altered reproductive and thyroid hormone levels during pregnancy. These changes may contribute to adverse health effects in mothers or their offspring, but additional research is required.
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影响因子：
11.8
作者：
Cantonwine, David E.;Cordero, Jose F.;Rivera-Gonzalez, Luis O.;Del Toro, Liza V. Anzalota;Ferguson, Kelly K.;Mukherjee, Bhramar;Calafat, Antonia M.;Crespo, Noe;Jimenez-Velez, Braulio;Padilla, Ingrid Y.;Alshawabkeh, Akram N.;Meeker, John D.
通讯作者：
Meeker, John D.
影响因子：
6.2
作者：
Casey, BM
通讯作者：
Casey, BM
影响因子：
10.4
作者：
Chevrier, Jonathan;Gunier, Robert B.;Harley, Kim G.
通讯作者：
Harley, Kim G.
关于出生结果和脂肪因子表达的母体和脐带血液中双酚A浓度的生物监测：台湾的一项出生队列研究。
DOI：
10.1186/1476-069x-10-94
发表时间：
2011-11-03
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Chou WC;Chen JL;Lin CF;Chen YC;Shih FC;Chuang CY
通讯作者：
Chuang CY
影响因子：
10.4
作者：
Meeker JD;Yang T;Ye X;Calafat AM;Hauser R
通讯作者：
Hauser R