Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression.
Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression.
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DOI：
10.1093/molbev/msaa128
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发表时间：
2020-10-01
影响因子：
10.7
通讯作者：
Anopheles gambiae 1000 Genomes Consortium
中科院分区：
文献类型：
--
作者：
Grau-Bové X;Tomlinson S;O'Reilly AO;Harding NJ;Miles A;Kwiatkowski D;Donnelly MJ;Weetman D;Anopheles gambiae 1000 Genomes Consortium
疟疾病媒按蚊自然种群中杀虫剂抗药性机制的演变是整个非洲的一个主要公共卫生问题。使用基因组序列数据，我们研究了抗性突变的演变，狄氏剂位点（Rdl），GABA受体的几种杀虫剂的目标，但最值得注意的是由长期中断的环二烯，狄氏剂。两种Rdl抗性突变（296G和296S）通过两次独立的硬选择性扫描（包括可能的补偿性邻近突变）在西非和中非按蚊中传播，随后是跨物种（从冈比亚按蚊和阿拉伯按蚊到科鲁兹按蚊）和跨2La染色体倒位的不一致核型的基因渗入的罕见组合。在20世纪50年代，作为第一个已知的对大规模基于疟疾的干预措施的适应，Rdl抗性进化，但是从这个系统中的进化教训突出了旨在对抗疟疾媒介抗性发展的管理策略的当代和未来的危险。
The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across nonconcordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.
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影响因子：
64.8
作者：
DAVIDSON, G
通讯作者：
DAVIDSON, G
影响因子：
10.7
作者：
Minh BQ;Nguyen MA;von Haeseler A
通讯作者：
von Haeseler A
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS
影响因子：
3
作者：
Chaccour CJ;Kobylinski KC;Bassat Q;Bousema T;Drakeley C;Alonso P;Foy BD
通讯作者：
Foy BD