Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination.
Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination.
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DOI：
10.1186/1475-2875-12-153
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发表时间：
2013-05-07
期刊：
影响因子：
3
通讯作者：
Foy BD
中科院分区：
文献类型：
--
作者：
Chaccour CJ;Kobylinski KC;Bassat Q;Bousema T;Drakeley C;Alonso P;Foy BD
疟疾传播的异质性使得广泛消灭疟疾成为一个难以实现的目标。目前大多数病媒控制措施没有充分针对室外传播。此外，杀虫剂抗药性有可能降低最普遍的措施-室内滞留喷洒和驱虫蚊帐-的效力。需要采取创新办法。使用伊维菌素等杀内外寄生虫剂可能是抗疟疾措施工具箱中的一个重要新补充。伊维菌素有效地针对户外传播，具有一种新的作用机制，可以避免耐药性，并可能通过现有的渠道分布，以控制盘尾丝虫病和淋巴丝虫病。对伊维菌素与媒介按蚊的关系进行了综述。还提供了伊维菌素安全性的审查。最后，三个明确的临床试验进行了详细描述，并提出实施所需的证据。还提出了几个较小的和具体的支持性研究。伊维菌素的使用解决了未来病媒控制战略面临的许多挑战。它是一种安全有效的杀虫剂，25年前就被批准用于人类。最近的研究表明，它可能成为消除和根除疟疾工作中的一项有效和补充战略;然而，要使其成为现实，还需要进行深入研究。
The heterogeneity of malaria transmission makes widespread elimination a difficult goal to achieve. Most of the current vector control measures insufficiently target outdoor transmission. Also, insecticide resistance threatens to diminish the efficacy of the most prevalent measures, indoor residual spray and insecticide treated nets. Innovative approaches are needed. The use of endectocides, such as ivermectin, could be an important new addition to the toolbox of anti-malarial measures. Ivermectin effectively targets outdoor transmission, has a novel mechanism of action that could circumvent resistance and might be distributed over the channels already in place for the control of onchocerciasis and lymphatic filariasis. The previous works involving ivermectin and Anopheles vectors are reviewed and summarized. A review of ivermectin’s safety profile is also provided. Finally three definitive clinical trials are described in detail and proposed as the evidence needed for implementation. Several smaller and specific supportive studies are also proposed. The use of ivermectin solves many challenges identified for future vector control strategies. It is an effective and safe endectocide that was approved for human use more than 25 years ago. Recent studies suggest it might become an effective and complementary strategy in malaria elimination and eradication efforts; however, intensive research will be needed to make this a reality.
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DOI：
10.4269/ajtmh.2010.10-0033
发表时间：
2010-09-01
影响因子：
3.3
作者：
Gutman, Julie;Emukah, Emmanuel;Richards, Frank O., Jr.
通讯作者：
Richards, Frank O., Jr.
DOI：
10.1179/000349809x12459740922138
发表时间：
2009-09-01
影响因子：
--
作者：
Fritz, M. L.;Siegert, P. Y.;Miller, J. R.
通讯作者：
Miller, J. R.
影响因子：
2.1
作者：
Fritz, Megan L.;Walker, Edward D.;Miller, James R.
通讯作者：
Miller, James R.
影响因子：
15.8
作者：
Alonso PL;Brown G;Arevalo-Herrera M;Binka F;Chitnis C;Collins F;Doumbo OK;Greenwood B;Hall BF;Levine MM;Mendis K;Newman RD;Plowe CV;Rodríguez MH;Sinden R;Slutsker L;Tanner M
通讯作者：
Tanner M
影响因子：
11.8
作者：
Edi CV;Koudou BG;Jones CM;Weetman D;Ranson H
通讯作者：
Ranson H