Comparative genome analysis reveals an absence of leucine-rich repeat pattern-recognition receptor proteins in the kingdom Fungi.
Comparative genome analysis reveals an absence of leucine-rich repeat pattern-recognition receptor proteins in the kingdom Fungi.
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DOI：
10.1371/journal.pone.0012725
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发表时间：
2010-09-14
期刊：
影响因子：
3.7
通讯作者：
Talbot NJ
中科院分区：
文献类型：
--
作者：
Soanes DM;Talbot NJ
在植物和动物中，先天免疫是抵御微生物病原体攻击的第一道防线。细菌和真菌的特定分子特征可被模式识别受体识别，这些受体具有含有富含亮氨酸重复序列的胞外结构域。这些受体对微生物的识别会诱导防御反应，保护宿主免受潜在微生物的攻击。对 101 个物种的基因组序列（代表真核系统发育树的广泛横截面）的调查表明，真菌界中不存在含有富含亮氨酸的重复结构域的受体。然而，独特的是，真菌拥有腺苷酸环化酶，其中含有独特的富含亮氨酸的重复结构域，这已被证明可以作为至少一种真菌物种感知细菌存在的替代方法。有趣的是，形态上相似的渗透营养卵菌是原生藻菌分类上距离较远的成员，它们拥有与植物中发现的模式识别受体相似的结构域结构。模式识别受体的缺失表明真菌可能拥有新型模式识别受体，例如修饰的腺苷酸环化酶，或者依赖抗菌次级代谢产物的分泌来防止微生物攻击。真菌中缺乏模式识别受体，加上卵菌中丰富的模式识别受体，表明这可能是真菌界的独特特征，而不是渗透性生长形式的结果。
In plants and animals innate immunity is the first line of defence against attack by microbial pathogens. Specific molecular features of bacteria and fungi are recognised by pattern recognition receptors that have extracellular domains containing leucine rich repeats. Recognition of microbes by these receptors induces defence responses that protect hosts against potential microbial attack. A survey of genome sequences from 101 species, representing a broad cross-section of the eukaryotic phylogenetic tree, reveals an absence of leucine rich repeat-domain containing receptors in the fungal kingdom. Uniquely, however, fungi possess adenylate cyclases that contain distinct leucine rich repeat-domains, which have been demonstrated to act as an alternative means of perceiving the presence of bacteria by at least one fungal species. Interestingly, the morphologically similar osmotrophic oomycetes, which are taxonomically distant members of the stramenopiles, possess pattern recognition receptors with similar domain structures to those found in plants. The absence of pattern recognition receptors suggests that fungi may possess novel classes of pattern-recognition receptor, such as the modified adenylate cyclase, or instead rely on secretion of anti-microbial secondary metabolites for protection from microbial attack. The absence of pattern recognition receptors in fungi, coupled with their abundance in oomycetes, suggests this may be a unique characteristic of the fungal kingdom rather than a consequence of the osmotrophic growth form.
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影响因子：
1.5
作者：
Hirt, RP;Harriman, N;Embley, TM
通讯作者：
Embley, TM
影响因子：
11.6
作者：
Soanes, Darren M.;Richards, Thomas A.;Talbot, Nicholas J.
通讯作者：
Talbot, Nicholas J.
DOI：
10.1073/pnas.0502270102
发表时间：
2005-04-26
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
Shiu, SH;Bleecker, AB
通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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