Stimulus dependent diversity and stereotypy in the output of an olfactory functional unit.
Stimulus dependent diversity and stereotypy in the output of an olfactory functional unit.
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DOI：
10.1038/s41467-018-03837-1
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发表时间：
2018-04-09
影响因子：
16.6
通讯作者：
Rinberg D
中科院分区：
文献类型：
--
作者：
Arneodo EM;Penikis KB;Rabinowitz N;Licata A;Cichy A;Zhang J;Bozza T;Rinberg D
嗅觉输入由一系列功能单元（嗅小球）组织，每个单元将来自表达特定气味受体的感觉神经元的信息传递给一小群输出神经元，即僧帽/簇状（MT）细胞。MT细胞对气味物质的反应具有异质性，并且这些反应如何对刺激特征进行编码尚不清楚。我们在清醒的小鼠中记录了“姐妹”MT细胞的反应，这些细胞接收来自一个具有功能特征且经基因鉴定的嗅小球的输入，该嗅小球对应一种特定受体（M72）。尽管接收相似的输入，但姐妹MT细胞对大多数M72配体表现出时间上多样的、浓度依赖性的兴奋性和抑制性反应。相比之下，已知对M72亲和力最强的配体在姐妹MT细胞中引起时间上刻板的、早期兴奋性反应，且在一系列浓度下保持一致。我们的数据表明，有关配体亲和力的信息以一种对浓度耐受的方式，通过嗅小球功能单元内姐妹MT细胞活动的整体刻板性或多样性进行编码。
僧帽/簇状（MT）细胞连接到单个嗅小球，并接收来自表达相同气味受体的感觉神经元的输入。在此，作者报告称，连接到M72嗅小球的姐妹MT细胞对大多数M72配体表现出可变的反应，但对一种高亲和力的M72配体以可重复且刻板的方式作出反应。
Olfactory inputs are organized in an array of functional units (glomeruli), each relaying information from sensory neurons expressing a given odorant receptor to a small population of output neurons, mitral/tufted (MT) cells. MT cells respond heterogeneously to odorants, and how the responses encode stimulus features is unknown. We recorded in awake mice responses from “sister” MT cells that receive input from a functionally characterized, genetically identified glomerulus, corresponding to a specific receptor (M72). Despite receiving similar inputs, sister MT cells exhibit temporally diverse, concentration-dependent, excitatory and inhibitory responses to most M72 ligands. In contrast, the strongest known ligand for M72 elicits temporally stereotyped, early excitatory responses in sister MT cells, consistent across a range of concentrations. Our data suggest that information about ligand affinity is encoded in the collective stereotypy or diversity of activity among sister MT cells within a glomerular functional unit in a concentration-tolerant manner. Mitral/tufted (MT) cells connect to a single glomerulus and receive inputs from sensory neurons expressing the same odorant receptor. Here the authors report that sister MT cells connected to the M72 glomerulus exhibit variable responses to most M72 ligands but respond in a reproducible and stereotyped way to a high-affinity M72 ligand.
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影响因子：
64.8
作者：
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