Quantitative relationship between cerebrovascular network and neuronal cell types in mice.
Quantitative relationship between cerebrovascular network and neuronal cell types in mice.
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DOI：
10.1016/j.celrep.2022.110978
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发表时间：
2022-06-21
期刊：
影响因子：
8.8
通讯作者：
Kim, Yongsoo
中科院分区：
文献类型：
--
作者：
Wu, Yuan-ting;Bennett, Hannah C.;Chon, Uree;Vanselow, Daniel J.;Zhang, Qingguang;Munoz-Castarieda, Rodrigo;Cheng, Keith C.;Osten, Pavel;Drew, Patrick J.;Kim, Yongsoo
脑血管系统及其壁细胞必须满足大脑区域的能量需求，但它们与不同神经元细胞类型的空间关系在整个大脑中如何变化仍然是未知的。在这里，我们应用全脑映射的方法，全面定义之间的定量关系的血管系统，毛细血管周细胞，和多巴胺能和GABA能神经元，包括神经元型一氧化氮合酶阳性（nNOS+）神经元和它们的亚型在成年小鼠。我们的研究结果表明，高密度的血管与高流体传导性和毛细血管周细胞在初级运动感觉皮层相比，关联皮层，显示显着的正相关和负相关性，与能量需求的小白蛋白+和血管nNOS+神经元，分别。与初级运动感觉皮层相连的丘脑-纹状体区也显示出高密度的血管和周细胞，这表明运动感觉处理区有密集的能量支持。我们的细胞分辨率资源提供了机会，研究脑血管网络和神经元细胞组成之间的空间关系，在很大程度上研究不足的皮层下区域。Wu等人生成了脑血管、周细胞和神经元细胞类型图及其分布和空间关系，以了解小鼠脑能量基础设施的组织。与具有高密度nNOS神经元的关联区域相比，密集的脑血管网络支持具有富集的小白蛋白神经元的运动感觉回路的高能量需求。
The cerebrovasculature and its mural cells must meet brain regional energy demands, but how their spatial relationship with different neuronal cell types varies across the brain remains largely unknown. Here we apply brain-wide mapping methods to comprehensively define the quantitative relationships between the cerebrovasculature, capillary pericytes, and glutamatergic and GABAergic neurons, including neuronal nitric oxide synthase-positive (nNOS+) neurons and their subtypes in adult mice. Our results show high densities of vasculature with high fluid conductance and capillary pericytes in primary motor sensory cortices compared with association cortices that show significant positive and negative correlations with energy-demanding parvalbumin+ and vasomotor nNOS+ neurons, respectively. Thalamo-striatal areas that are connected to primary motor sensory cortices also show high densities of vasculature and pericytes, suggesting dense energy support for motor sensory processing areas. Our cellular-resolution resource offers opportunities to examine spatial relationships between the cerebrovascular network and neuronal cell composition in largely understudied subcortical areas. Wu et al. generate cerebrovascular, pericyte, and neuronal cell type maps with their distribution and spatial relationship to understand the organization of brain energy infrastructure in mice. Dense cerebrovascular networks support the high energy demand of motor sensory circuits with enriched parvalbumin neurons compared with association areas with a high density of nNOS neurons.
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影响因子：
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通讯作者：
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影响因子：
64.8
作者：
Harris JA;Mihalas S;Hirokawa KE;Whitesell JD;Choi H;Bernard A;Bohn P;Caldejon S;Casal L;Cho A;Feiner A;Feng D;Gaudreault N;Gerfen CR;Graddis N;Groblewski PA;Henry AM;Ho A;Howard R;Knox JE;Kuan L;Kuang X;Lecoq J;Lesnar P;Li Y;Luviano J;McConoughey S;Mortrud MT;Naeemi M;Ng L;Oh SW;Ouellette B;Shen E;Sorensen SA;Wakeman W;Wang Q;Wang Y;Williford A;Phillips JW;Jones AR;Koch C;Zeng H
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