The mouse cortico-basal ganglia-thalamic network.
The mouse cortico-basal ganglia-thalamic network.
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小鼠皮质-基底节-丘脑网络。
DOI：
10.1038/s41586-021-03993-3
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发表时间：
2021-10
期刊：
影响因子：
64.8
通讯作者：
Dong HW
中科院分区：
文献类型：
--
作者：
Foster NN;Barry J;Korobkova L;Garcia L;Gao L;Becerra M;Sherafat Y;Peng B;Li X;Choi JH;Gou L;Zingg B;Azam S;Lo D;Khanjani N;Zhang B;Stanis J;Bowman I;Cotter K;Cao C;Yamashita S;Tugangui A;Li A;Jiang T;Jia X;Feng Z;Aquino S;Mun HS;Zhu M;Santarelli A;Benavidez NL;Song M;Dan G;Fayzullina M;Ustrell S;Boesen T;Johnson DL;Xu H;Bienkowski MS;Yang XW;Gong H;Levine MS;Wickersham I;Luo Q;Hahn JD;Lim BK;Zhang LI;Cepeda C;Hintiryan H;Dong HW
皮质-基底节-丘脑-皮质环是大脑中的基本网络基序之一。揭示其结构和功能组织对于理解认知，感觉运动行为以及许多神经和神经精神疾病的自然史至关重要。传统上，这个网络被概念化为包含三个信息通道：运动通道、边缘通道和联想通道。然而，这种三通道的观点无法解释基底神经节的无数功能。我们以前细分为29个功能域的基础上，从整个皮层的输入地形背侧纹状体。在这里，我们映射这些纹状体域通过苍白球外部（GPe），黑质网状部分（SNr），丘脑核和皮质的多突触输出通路。因此，我们确定了14个SNr和36个GPe结构域和一个直接的皮质SNr投影。纹状体黑质直接途径显示更大的收敛纹状体输入比更平行的striatopallidal间接途径，虽然直接和间接途径起源于同一纹状体域最终收敛到相同的突触后SNr神经元。SNr输出后，我们描绘了6个领域的束旁核和丘脑腹内侧核。随后，我们确定了六个平行的皮质-基底节-丘脑子网络，它们通过皮质-基底节-丘脑回路的每个元素节点顺序地传递特定的皮质信息子集。丘脑域在一个真正的闭环中将此输出中继回每个子网络的起源皮质纹状体神经元。皮质-基底节-丘脑网络的中尺度连接组学映射揭示了关键的结构和信息处理特征。
The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history of many neurological and neuropsychiatric disorders. Classically, this network is conceptualized to contain three information channels: motor, limbic and associative. Yet this three-channel view cannot explain the myriad functions of the basal ganglia. We previously subdivided the dorsal striatum into 29 functional domains on the basis of the topography of inputs from the entire cortex. Here we map the multi-synaptic output pathways of these striatal domains through the globus pallidus external part (GPe), substantia nigra reticular part (SNr), thalamic nuclei and cortex. Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection. The striatonigral direct pathway displays a greater convergence of striatal inputs than the more parallel striatopallidal indirect pathway, although direct and indirect pathways originating from the same striatal domain ultimately converge onto the same postsynaptic SNr neurons. Following the SNr outputs, we delineate six domains in the parafascicular and ventromedial thalamic nuclei. Subsequently, we identify six parallel cortico–basal ganglia–thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico–basal ganglia–thalamic loop. Thalamic domains relay this output back to the originating corticostriatal neurons of each subnetwork in a bona fide closed loop. Mesoscale connectomic mapping of the cortico–basal ganglia–thalamic network reveals key architectural and information processing features.
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影响因子：
11
作者：
Haroon E;Fleischer CC;Felger JC;Chen X;Woolwine BJ;Patel T;Hu XP;Miller AH
通讯作者：
Miller AH
影响因子：
16.2
作者：
Ding L;Gold JI
通讯作者：
Gold JI
影响因子：
3.1
作者：
Harrington, Deborah L.;Liu, Dawei;Smith, Megan M.;Mills, James A.;Long, Jeffrey D.;Aylward, Elizabeth H.;Paulsen, Jane S.
通讯作者：
Paulsen, Jane S.
影响因子：
2.5
作者：
GERFEN, CR
通讯作者：
GERFEN, CR
影响因子：
2.9
作者：
FILION, M;TREMBLAY, L;BEDARD, PJ
通讯作者：
BEDARD, PJ