The effect of different photoperiods in circadian rhythms of per3 knockout mice.
The effect of different photoperiods in circadian rhythms of per3 knockout mice.
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DOI：
10.1155/2014/170795
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发表时间：
2014
影响因子：
--
通讯作者：
Pedrazzoli M
中科院分区：
文献类型：
--
作者：
Pereira DS;van der Veen DR;Gonçalves BS;Tufik S;von Schantz M;Archer SN;Pedrazzoli M
本研究的目的是分析携带per3基因功能敲除(per3−/−)的小鼠对不同的光 ： 暗(L ： D)周期的昼夜行为反应。将雄性成年野生型(WT)和PER3−/−小鼠置于12小时光照 ： 12小时黑暗条件(12L ： 12D)中，然后转换到短光或长光周期，然后释放到完全黑暗中。所有小鼠都暴露在这两种条件下，通过跑轮活动获得行为活动数据，并分析这些条件下的昼夜节律特征。我们观察到，在从12L ： 12D到16L ： 8D的过渡过程中，与WT小鼠相比，PER3−/−小鼠大约多花了一天时间来同步到新的L ： D周期。在这些长光周期条件下，PER3−/−小鼠在光相中更活跃。我们的结果表明，PER3−/−小鼠对光不那么敏感。这里提供的数据提供了进一步的证据，表明PER3参与了对光的直接反应的行为活动的抑制。
The aim of this study was to analyse the circadian behavioural responses of mice carrying a functional knockout of the Per3 gene (Per3−/−) to different light : dark (L : D) cycles. Male adult wild-type (WT) and Per3−/− mice were kept under 12-hour light : 12-hour dark conditions (12L : 12D) and then transferred to either a short or long photoperiod and subsequently released into total darkness. All mice were exposed to both conditions, and behavioural activity data were acquired through running wheel activity and analysed for circadian characteristics during these conditions. We observed that, during the transition from 12L : 12D to 16L : 8D, Per3−/− mice take approximately one additional day to synchronise to the new L : D cycle compared to WT mice. Under these long photoperiod conditions, Per3−/− mice were more active in the light phase. Our results suggest that Per3−/− mice are less sensitive to light. The data presented here provides further evidence that Per3 is involved in the suppression of behavioural activity in direct response to light.
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影响因子：
2.8
作者：
MARQUES, MD;WATERHOUSE, JM
通讯作者：
WATERHOUSE, JM
影响因子：
3.5
作者：
Nadkarni, NA;Weale, ME;Thomas, MG
通讯作者：
Thomas, MG
影响因子：
11.4
作者：
Takumi, T;Taguchi, K;Okamura, H
通讯作者：
Okamura, H
DOI：
10.1038/nrg2430
发表时间：
2008-10
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.2
作者：
Viola, Antoine U.;Archer, Simon N.;Dijk, Derk-Jan
通讯作者：
Dijk, Derk-Jan