The genetics of mammalian circadian order and disorder: implications for physiology and disease.
The genetics of mammalian circadian order and disorder: implications for physiology and disease.
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DOI：
10.1038/nrg2430
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发表时间：
2008-10
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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昼夜节律影响各种生理过程，因此，正常昼夜节律的破坏有可能影响一系列与疾病相关的途径。昼夜节律的遗传基础在模式生物中得到了很好的研究，最近对昼夜节律紊乱的遗传基础的研究证实，从无脊椎动物到人类，昼夜节律生物学中的关键角色都是保守的。此外，在了解这些分子如何影响全身组织的生理功能方面也取得了重要进展。总而言之，这些研究为将我们的昼夜生物学知识应用于理解和治疗一系列人类疾病奠定了基础，包括癌症、代谢和行为障碍。
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer, and metabolic and behavioural disorders.
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影响因子：
64.8
作者：
Cheng, MY;Bullock, CM;Zhou, QY
通讯作者：
Zhou, QY
DOI：
10.1073/pnas.0707772105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Brown, Steven A.;Kunz, Dieter;Kramer, Achim
通讯作者：
Kramer, Achim
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U
影响因子：
5.3
作者：
Eide, EJ;Woolf, MF;Virshup, DM
通讯作者：
Virshup, DM
影响因子：
64.8
作者：
Cirelli, C;Bushey, D;Tononi, G
通讯作者：
Tononi, G