Maternal helminth infections.

Maternal helminth infections.
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孕产妇蠕虫感染

DOI:
10.1007/978-1-4939-1489-0_2
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发表时间:
2014
影响因子:
--
通讯作者:
Prazeres da Costa C
Prazeres da Costa C
中科院分区:
医学4区
文献类型:
--
作者:
Straubinger K;Prazeres da Costa C

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慢性蠕虫感染在世界许多地区非常普遍,据报道,怀孕期间的感染率相当高。越来越清楚的是,胎儿免疫系统的发育以及以后对同源甚至异源抗原的免疫反应已经在子宫内决定了。影响因素和机制仍在调查中。然而,研究表明,母体蠕虫感染可以影响儿童时期对同源感染的易感性,而在怀孕期间没有感染因子本身的母婴传播。这是否由慢性母体免疫反应(细胞或细胞因子)引起,如免疫调节或蠕虫衍生抗原/蛋白质的传播,以及后代免疫系统的哪个发育阶段受到这些因素的影响,如以表观遗传方式,最后,这些结果对疫苗接种策略有什么临床意义,需要在未来进行研究。
Chronic helminth infections are highly prevalent in many parts of the world and a considerable infection rate during pregnancy has been reported. It is becoming clear that the development of the fetal immune system and the immune responses to homologous and possibly even heterologous antigens later in life is already determined in utero. The contributing factors and mechanisms are still under investigation. However, studies have demonstrated that maternal helminth infection can influence susceptibility to a homologous infection during childhood without previous fetomaternal transmission of the infectious agent itself during pregnancy. Whether this is caused e.g. by chronic maternal immune responses (cells or cytokines) such as immuneregulation or transmission of helminth derived antigen/proteins, and furthermore which developmental stage of the offspring’s immune system is affected by such factors e.g. in an epigenetic manner and finally, what clinical implications these results have regarding vaccination strategies, needs to be investigated in the future.
母乳喂养影响下的新生儿耐受性:母乳中过敏原和转化生长因子-β的存在可以保护后代免受过敏性哮喘的影响。
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