An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies.
An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies.
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DOI：
10.3390/v13010011
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发表时间：
2020-12-23
期刊：
影响因子：
--
通讯作者：
Twarock R
中科院分区：
文献类型：
--
作者：
Fatehi F;Bingham RJ;Dykeman EC;Patel N;Stockley PG;Twarock R
B型肝炎病毒（HBV）是世界范围内抗病毒研究的主要焦点。国际消除乙型肝炎联盟与世界卫生组织（WHO）一起优先寻求治疗方法，目标是到2030年消除病毒性肝炎死亡。我们在这里提出了一个全面的细胞内HBV感染动力学模型，包括目前药物靶向的所有分子过程，并与几项临床研究的观察结果一致。该模型揭示了亚病毒颗粒形成过程中先前未被怀疑的动力学行为，这可能有助于更好地了解感染的免疫反应。它还可以快速比较评估不同治疗方案的影响及其作为联合治疗的潜在协同作用。可用的和目前开发的治疗方案的比较表明，多种衣壳组装抑制剂的组合表现最好。
Hepatitis B virus (HBV) is a major focus of antiviral research worldwide. The International Coalition to Eliminate HBV, together with the World Health Organisation (WHO), have prioritised the search for a cure, with the goal of eliminating deaths from viral hepatitis by 2030. We present here a comprehensive model of intracellular HBV infection dynamics that includes all molecular processes currently targeted by drugs and agrees well with the observed outcomes of several clinical studies. The model reveals previously unsuspected kinetic behaviour in the formation of sub-viral particles, which could lead to a better understanding of the immune responses to infection. It also enables rapid comparative assessment of the impact of different treatment options and their potential synergies as combination therapies. A comparison of available and currently developed treatment options reveals that combinations of multiple capsid assembly inhibitors perform best.
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DOI：
10.3390/v9030056
发表时间：
2017-03-21
期刊：
Viruses
影响因子：
--
作者：
Hu J;Liu K
通讯作者：
Liu K
影响因子：
4.3
作者：
Ciupe SM;Ribeiro RM;Perelson AS
通讯作者：
Perelson AS
影响因子：
2
作者：
Jansen, Martin;Pfaffelhuber, Peter
通讯作者：
Pfaffelhuber, Peter
影响因子：
4.9
作者：
Berke, Jan Martin;Dehertogh, Pascale;Pauwels, Frederik
通讯作者：
Pauwels, Frederik
影响因子：
8
作者：
Balagopal, Ashwin;Grudda, Tanner;Thio, Chloe L.
通讯作者：
Thio, Chloe L.