Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy.
Comparing imaging capabilities of spectral domain and swept source optical coherence tomography angiography in healthy subjects and central serous retinopathy.
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DOI：
10.1186/s40662-018-0113-2
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wang RK
中科院分区：
文献类型：
--
作者：
Wang F;Zhang Q;Deegan AJ;Chang J;Wang RK
在眼科成像中存在两种形式的光学相干断层扫描血管造影术（OCTA）的系统实现，即，谱域（SD-）和扫频源OCTA（SS-OCTA）。本文的目的是比较SD-OCTA和SS-OCTA，以阐明与中心性浆液性视网膜病变（CSR）相关的结构和血管特征，并评估CSR对SD-和SS-OCTA成像能力的影响。正常受试者和CSR患者使用3 × 3 mm和6 × 6 mm扫描模式通过SD-和SS-OCTA成像。OCT信号强度在浅视网膜，深视网膜，Sattler的层和Haller的层被用来比较SD和SS-OCTA图像结构特征的能力。此外，通过评估视网膜血管密度讨论了获取血管造影片的能力。测量了中心浆液体积（CSV），并将其与两种OCTA设备之间的信号强度差异（CSV）相关。7只正常眼和7只患病眼被招募。结果显示，根据配对t检验，SD-和SS-OCT在检测视网膜层结构特征方面无显著差异。然而，当对正常眼的Sattler层成像时，SD-和SS-OCT之间存在显著差异（3 × 3 mm扫描p < 0.0001，6 × 6 mm扫描p = 0.0002）;而对于CSR眼，相应值分别为p < 0.0001和p = 0.0003。在正常眼的Haller层，相应值分别为p = 0.0004和p = 0.0014;对于CSR眼，分别为p = 0.0004和p < 0.0001。在Sattler's层中观察到了Cysts和CSV之间的强相关性（3 × 3 mm - p = 0.0031和R2 = 0.951; 6 × 6 mm - p = 0.0075和R2 = 0.911）和Haller层（3 × 3 mm - p = 0.0026和R2 = 0.955; 6 × 6 mm - p = 0.0013和R2 = 0.972）。结果表明，SD-和SS-OCTA对视网膜层成像没有差异，但是，当成像超过视网膜层时，SS-OCTA在检测返回信号方面似乎是有利的。在CSR病例中，CSV可能对亚CSR组织成像产生影响，并且似乎对SD-的影响大于SS-OCTA。
There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA’s imaging capabilities. Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns. OCT signal strengths at the superficial retina, deep retina, Sattler’s layer and Haller’s layer were used to compare the ability of SD- and SS-OCTA to image structural features. In addition, the ability to acquire angiograms were discussed by evaluating retinal vessel density. Central serous volume (CSV) was measured and it was correlated with difference in signal strengths (∆S) between two OCTA devices. Seven normal eyes and seven diseased eyes were recruited. Results showed no significant differences between SD- and SS-OCT in detecting structural features of the retinal layer according to the paired t-test. However, when imaging the Sattler’s layer for normal eyes, a significant difference is found between SD- and SS-OCT (p < 0.0001 for 3 × 3 mm scan, and p = 0.0002 for 6 × 6 mm); while for CSR eyes, the corresponding values were p < 0.0001 and p = 0.0003, respectively. At Haller’s layer for normal eyes, the corresponding values were p = 0.0004 and p = 0.0014; and for CSR eyes, p = 0.0004 and p < 0.0001, respectively. A strong correlation between ∆S and CSV was observed in the Sattler’s layer (3 × 3 mm – p = 0.0031 and R2 = 0.951; 6 × 6 mm – p = 0.0075 and R2 = 0.911) and Haller’s layer (3 × 3 mm – p = 0.0026 and R2 = 0.955; 6 × 6 mm – p = 0.0013 and R2 = 0.972). The results suggest no differences between SD- and SS-OCTA for imaging the retinal layers however, when imaging beyond retinal layers, SS-OCTA appears advantageous in detecting returning signals. In CSR cases, the CSV may have an impact on sub-CSR tissue imaging and appears to have more impact on SD- than SS-OCTA.
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影响因子：
3.7
作者：
Baumal, C R
通讯作者：
Baumal, C R
DOI：
10.3928/23258160-20140909-08
发表时间：
2014-09
期刊：
Ophthalmic surgery, lasers & imaging retina
影响因子：
--
作者：
Huang Y;Zhang Q;Thorell MR;An L;Durbin MK;Laron M;Sharma U;Gregori G;Rosenfeld PJ;Wang RK
通讯作者：
Wang RK
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
影响因子：
3.3
作者：
Giavarina D
通讯作者：
Giavarina D
DOI：
10.2307/2987937
发表时间：
1983-01-01
期刊：
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES D-THE STATISTICIAN
影响因子：
--
作者：
ALTMAN, DG;BLAND, JM
通讯作者：
BLAND, JM