Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms.

Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms.
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DOI:
10.3928/23258160-20140909-08
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发表时间:
2014-09
期刊:
Ophthalmic surgery, lasers & imaging retina
影响因子:
--
通讯作者:
Wang RK
Wang RK
中科院分区:
其他
文献类型:
--
作者:
Huang Y;Zhang Q;Thorell MR;An L;Durbin MK;Laron M;Sharma U;Gregori G;Rosenfeld PJ;Wang RK

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To demonstrate the feasibility of using a 1050 nm swept-source OCT (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. Volumetric datasets were acquired using a ZEISS 1 µm SS-OCT prototype that operated at an A-line rate of 100 kHz. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan ~3 mm × 3 mm area in the central macular region of the retina within ~4.5 seconds. Intensity differentiation based OMAG algorithm was used to extract 3-D retinal functional microvasculature information. Intensity signal differentiation generated capillary-level resolution en face OMAG images of the retina. The parafoveal capillaries were clearly visible, thereby allowing visualization of the foveal avascular zone (FAZ) in normal subjects. The capability of OMAG to produce retinal vascular images was demonstrated using the ZEISS 1 µm SS-OCT prototype. This technique can potentially have clinical value for studying retinal vasculature abnormalities.
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