Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study.
Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study.
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DOI：
10.1007/s10554-014-0532-7
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发表时间：
2015-01
影响因子：
2.1
通讯作者：
Yuan, Chun
中科院分区：
文献类型：
--
作者：
Sun, Jie;Zhao, Xue-Qiao;Balu, Niranjan;Hippe, Daniel S.;Hatsukami, Thomas S.;Isquith, Daniel A.;Yamada, Kiyofumi;Neradilek, Moni B.;Canton, Gador;Xue, Yunjing;Fleg, Jerome L.;Desvigne-Nickens, Patrice;Klimas, Michael T.;Padley, Robert J.;Vassileva, Maria T.;Wyman, Bradley T.;Yuan, Chun
本研究旨在确定磁共振成像（MRI）的多中心再现性和不同扫描仪平台在评估颈动脉斑块形态和组成方面的兼容性。在16个成像中心（GE：8个; Philips：8个）实施了标准化的多对比度MRI方案。68名受试者（61 ± 8岁; 52名男性）被分散招募，并在2周内在同一磁体上扫描两次。使用简化的半自动方法集中审查图像。获得斑块形态（管腔、壁和外壁）和斑块组织成分[富脂坏死核心（LRNC）、钙化和纤维组织]的定量体积测量值。使用受试者内标准差、变异系数（CV）和组内相关系数（ICC）总结扫描间重现性。观察到形态（ICC范围0.98-0.99）和组成（ICC范围0.88-0.96）测量的良好至优异的再现性。测量精度与结构尺寸相关（形态学的CV范围为2.5- 4.9%，LRNC和钙化的CV范围为36- 44%）。在斑块形态和组织组成方面，两个平台之间的测量变异性相当。总之，在多中心环境中，颈动脉MRI的扫描间重现性可以达到良好至优异，平台之间的测量精度相当，这可能有助于未来使用连续MRI监测动脉粥样硬化斑块进展的多中心努力。
This study sought to determine the multicenter reproducibility of magnetic resonance imaging (MRI) and the compatibility of different scanner platforms in assessing carotid plaque morphology and composition. A standardized multi-contrast MRI protocol was implemented at 16 imaging sites (GE: 8; Philips: 8). Sixty-eight subjects (61 ± 8 years; 52 males) were dispersedly recruited and scanned twice within 2 weeks on the same magnet. Images were reviewed centrally using a streamlined semiautomatic approach. Quantitative volumetric measurements on plaque morphology (lumen, wall, and outer wall) and plaque tissue composition [lipid-rich necrotic core (LRNC), calcification, and fibrous tissue] were obtained. Inter-scan reproducibility was summarized using the within-subject standard deviation, coefficient of variation (CV) and intraclass correlation coefficient (ICC). Good to excellent reproducibility was observed for both morphological (ICC range 0.98–0.99) and compositional (ICC range 0.88–0.96) measurements. Measurement precision was related to the size of structures (CV range 2.5–4.9 % for morphology, 36–44 % for LRNC and calcification). Comparable measurement variability was found between the two platforms on both plaque morphology and tissue composition. In conclusion, good to excellent inter-scan reproducibility of carotid MRI can be achieved in multicenter settings with comparable measurement precision between platforms, which may facilitate future multicenter endeavors that use serial MRI to monitor atherosclerotic plaque progression.
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影响因子：
4.8
作者：
Brown, B. Gregory;Boden, William E.;Probstfield, Jeffrey R.;McBride, Ruth;Anderson, Todd;Chaitman, Bernard;Marcovina, Santica;Weintraub, William;Zhao, Xue-Qiao;Teo, Koon;Kaiser, Judith;Desvignes-Nickens, Patrice;Fleg, Jerome L.;McGovern, Mark E.;Stolzenbach, James C.;Padley, Robert J.
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影响因子：
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作者：
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通讯作者：
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影响因子：
19.7
作者：
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