Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?
Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?
复制标题
将DMN连接连接到情节记忆力：我们可以从颞叶内侧损伤的患者那里学到什么？
DOI：
10.1016/j.nicl.2014.05.008
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
McAndrews MP
中科院分区：
文献类型：
--
作者：
McCormick C;Protzner AB;Barnett AJ;Cohn M;Valiante TA;McAndrews MP
计算模型预测，默认模式网络（DMN）的局灶性损伤会导致DMN功能连通性的广泛减少和增加。这种改变是如何影响特定认知领域的功能的，比如情景记忆，目前还没有研究。本研究表明，在单侧内侧颞叶癫痫（mTLE）患者中，局灶性结构损伤确实导致DMN功能连通性的特定模式改变，特别是内侧颞叶（MTLs）和DMN后部之间的连通性下降，以及半球内前后连通性增加。重要的是，这些模式分别与更好和更差的情景记忆能力有关。这些不同的模式，首次在这里显示，表明mtl和DMN的后侧成分之间的密切对话是充分表达广泛的情景记忆能力所必需的。mTLE的局灶性结构损伤与DMN的广泛功能改变有关。更大的DMN连接改变反映了更差的临床记忆测量。结构完整性调节功能连通性对记忆的影响。后颞叶皮层与后颞叶皮层的半球间整合可能是改善记忆的关键。
Computational models predict that focal damage to the Default Mode Network (DMN) causes widespread decreases and increases of functional DMN connectivity. How such alterations impact functioning in a specific cognitive domain such as episodic memory remains relatively unexplored. Here, we show in patients with unilateral medial temporal lobe epilepsy (mTLE) that focal structural damage leads indeed to specific patterns of DMN functional connectivity alterations, specifically decreased connectivity between both medial temporal lobes (MTLs) and the posterior part of the DMN and increased intrahemispheric anterior–posterior connectivity. Importantly, these patterns were associated with better and worse episodic memory capacity, respectively. These distinct patterns, shown here for the first time, suggest that a close dialogue between both MTLs and the posterior components of the DMN is required to fully express the extensive repertoire of episodic memory abilities. Focal structural damage correlates with widespread functional change in DMN in mTLE. Greater DMN connectivity alterations reflect worse clinical memory measures. Structural integrity moderates influence of functional connectivity on memory. Interhemispheric integration of MTL into posterior DMN may be key to better memory.
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