The evolving landscape of human cortical connectivity: facts and inferences.
The evolving landscape of human cortical connectivity: facts and inferences.
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DOI：
10.1016/j.neuroimage.2011.12.033
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发表时间：
2012-10-01
期刊：
影响因子：
5.7
通讯作者：
Mesulam, Marsel
中科院分区：
文献类型：
--
作者：
Mesulam, Marsel
人类认知脑图谱正处于十字路口。一方面，它可以访问猴子大脑皮层突触连接的丰富数据集，而猴子这种动物缺乏许多令人感兴趣的复杂行为。另一方面，它在人类大脑皮层的功能地图上迅速积累了更丰富的数据集，但在潜在的结构连接上却相对较少的硬数据。由于“连接”一词在人类大脑的语境中有多种使用方式，因此在当前的文献中，第二点往往是模糊的。在某些情况下，该术语在概念层面上使用，用于指定要执行行为时应该存在的路径。在其他情况下，它指的是函数关系的计算演示，其结构基础不一定是已知的。第三种用法是基于已知存在于猴子和推断也存在于人类的连接。第四个也是最直接的用法涉及到从结构上证明存在于人类中的连接。这四种用法被交替调用，以提出人类认知功能的连接机制。扩大目前有限的结构连接数据集对于进行更有效的大规模神经认知网络的生物学探索具有相当重要的意义。这一具有挑战性的目标将要求人类大脑的组织学实验室研究恢复其以往的突出地位，并在大脑测绘研究中发挥越来越重要的作用。
Human cognitive brain mapping is at a crossroads. On the one hand, it can access a rich data set of synaptic connectivity in the cerebral cortex of the monkey, an animal that lacks many of the complicated behaviors of interest. On the other hand, it is rapidly amassing an even richer data set on the functional map of the human cerebral cortex, but with relatively little hard data on underlying structural connectivity. This second point tends to be blurred in the current literature because of the multiple ways in which the term ‘connection’ is used in the context of the human brain. In some instances the term is used at a conceptual level, to designate a pathway that should be there if the behavior is to be performed. In other instances, it refers to the computational demonstration of a functional relationship, the structural basis of which is not necessarily known. A third usage is based on connections that are known to exist in the monkey and that are inferred to also exist in the human. The fourth and most direct usage involves connections structurally proven to exist in the human. These four usages have been invoked interchangeably to propose connectivistic mechanisms of human cognitive function. To enlarge the currently limited data set on structural connectivity is of considerable importance for conducting biologically more valid explorations of large-scale neurocognitive networks. This challenging goal will require histological laboratory investigations of the human brain to resume their former prominence and to play an increasingly more substantial role in brain mapping research.
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影响因子：
5.7
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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