Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.
Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.
复制标题
灵芝多糖增强薏苡仁油微乳稳定性及肺癌靶向治疗
DOI：
10.1080/10717544.2018.1516006
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发表时间：
2018-11
期刊：
影响因子：
6
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Guo J;Yuan C;Huang M;Liu Y;Chen Y;Liu C;Chen Y
摘要本研究旨在探讨灵芝多糖（GLP）对薏苡仁油微乳制剂性能及抗肺癌治疗作用的影响。GLP-整合的薏苡油微乳液（MEs（PS-GLP））具有清晰的球形形状、较小的粒径和与薏苡油微乳液相似的良好的流体力学性能，但表现出较低的zeta电位和较好的稳定性。荧光共振能量转移分析表明，GLP与微乳液结合为单一体系。值得注意的是，多糖和微乳液之间的平均分子距离约为1.7 nm。MEs（PS-GLP）对A549细胞的半最大抑制浓度约为119 μg/mL。体内成像研究表明，GLP的引入促进了微乳的肿瘤特异性蓄积。体内抗肿瘤实验表明，MEs（PS-GLP）能显著抑制A549荷瘤裸鼠的肿瘤生长，并能明显提高其血清免疫指标。本研究揭示了多糖与微乳空间关系的潜在机制，验证了GLP对肿瘤蓄积和抗肿瘤作用的意义。
Abstract The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microemulsion on pharmaceutical performance and anti-lung cancer treatment. GLP-integrated coix oil-based microemulsion (MEs(PS-GLP)) exhibited a clear spherical shape, small particle size, and good hydrodynamics similar to the coix oil-based microemulsion, but showed a lower zeta potential and a better stability. Fluorescence resonance energy transfer analysis presented that GLP was integrated with microemulsion as a single system. Notably, the average molecular distance between polysaccharide and microemulsion was approximately 1.7 nm. The half-maximal inhibitory concentration of MEs(PS-GLP) against A549 cells was about 119 μg/mL. In vivo imaging studies showed that introduction of GLP promoted the tumor-specific accumulation of microemulsion in comparison with controls. In vivo, antitumor results showed that MEs(PS-GLP) markedly inhibited the tumor growth of A549-bearing xenograft nude mice and obviously improve the serum immune index. Collectively, this study demonstrates the potential mechanism of spatial relation between polysaccharides and microemulsion and validates the significances of GLP on tumoral accumulation and antitumor efficacy.
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