Cutaneous mucormycosis.

Cutaneous mucormycosis.
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DOI:
10.1590/abd1806-4841.20176614
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发表时间:
2017-05
影响因子:
1.7
通讯作者:
Welsh O
Welsh O
中科院分区:
医学4区
文献类型:
--
作者:
Castrejón-Pérez AD;Welsh EC;Miranda I;Ocampo-Candiani J;Welsh O

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皮肤毛霉病是由球菌门的机会性真菌引起的一种新的真菌感染。常见于控制不佳的糖尿病患者和有免疫抑制的个体。通常是通过创伤直接接种获得的。临床表现无特异性,但硬化斑块迅速演变为坏死是常见的发现。诊断应该通过病原体的证明来确认,最近已经描述了新的分子诊断工具。它是一种侵袭性的危及生命的疾病,为了提高存活率,应该提供及时的诊断和多学科的治疗。治疗的选择是两性霉素B,但必须考虑新的唑类,如泊沙康唑和异武康唑。
Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described. It is an invasive life-threatening disease and in order to improve survival, a prompt diagnosis and multidisciplinary management should be provided. The treatment of choice is amphotericin B, but new azoles, such as posaconazole and isavuconazole, must be considered.
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