Competing interplay between systemic and periodontal inflammation: obesity overrides the impact of oral periphery.
Competing interplay between systemic and periodontal inflammation: obesity overrides the impact of oral periphery.
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DOI：
10.1007/s00784-020-03514-y
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发表时间：
2021-04
影响因子：
3.4
通讯作者：
Kocher T
中科院分区：
文献类型：
--
作者：
Meisel P;Pink C;Pitchika V;Nauck M;Völzke H;Kocher T
我们的目的是研究局部炎症、牙周炎和肥胖之间的相互作用是否与全身性炎症独立相关。来自波美拉尼亚以人群为基础的健康研究，研究了3366名没有（2366）肥胖和（1000）肥胖的参与者与牙周炎的关系，测量方法为探探深度（PD）和斑块以及c反应蛋白（CRP）的体重指数（BMI）。分位数回归用于评估牙周、人体测量和炎症变量（结果）之间的关联。成年人群中肥胖的总体患病率为男性31.4%，女性28.1%。PD和斑块均与CRP呈正相关，表明CRP浓度分布的影响越来越大。调整CRP或纤维蛋白原对PD的回归对腰围的影响减弱，但没有消除PD系数。牙菌斑与这些相互关系相似。在低、中、高风险CRP浓度的受试者中，PD与牙菌斑之间的关联是不同的。局部和全身炎症源影响血液中炎症标志物的水平。各自的贡献取决于每种炎症诱导风险的相对比率，并以肥胖为主。保持全身炎症低，以防止与年龄有关的疾病的后遗症。本文的在线版本（10.1007/s00784-020-03514-y）包含补充资料，仅供授权用户使用。
We aimed at investigating whether the interaction between the local inflammation, periodontitis, and obesity is independently associated with systemic inflammation. From the population-based Study of Health in Pomerania, 3366 participants, without (2366) and with (1000) obesity, were studied for the association of periodontitis, measured as probing depth (PD) and plaque together with body mass index (BMI) on C-reactive protein (CRP). Quantile regression was used to evaluate the association between periodontal, anthropometric, and inflammatory variables (outcomes). The overall prevalence of obesity in this adult population was 31.4% in men and 28.1% in women. Both PD and plaque were positively associated with CRP, revealing an increasing impact across the CRP concentration distribution. Adjusting the regression of CRP or fibrinogen on PD for waist circumference attenuated but did not abolish the PD coefficients. Dental plaque was similarly associated with these interrelations. Association between PD and a dental plaque was different among participants with low-, medium-, or high-risk CRP concentrations. Local and systemic sources of inflammation contribute to blood levels of inflammatory markers. The respective contributions depend on the relative rate in each of the inflammation-inducing risks and are dominated by adiposity. Keeping systemic inflammation low in order to prevent age-related disease sequelae. The online version of this article (10.1007/s00784-020-03514-y) contains supplementary material, which is available to authorized users.
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