Progress towards a glycoconjugate vaccine against Group A Streptococcus.
Progress towards a glycoconjugate vaccine against Group A Streptococcus.
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DOI：
10.1038/s41541-023-00639-5
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发表时间：
2023-03-28
期刊：
影响因子：
9.2
通讯作者：
中科院分区：
文献类型：
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作者：
A组碳水化合物（GAC）是A组链球菌（Strep A）或化脓性链球菌的定义特征。它是一种保守的简单多糖，包含鼠李糖主链和GlcNAc侧链，在约40%的GlcNAc残基上进一步用磷酸甘油修饰。它的保守性、表面暴露性和抗原性使其成为A型链球菌疫苗设计的一个有趣的焦点。含有这种保守碳水化合物的糖缀合物应该是成功完成构建通用A型链球菌候选疫苗的使命的关键方法。在这篇综述中，简要介绍了GAC，链球菌A的主要碳水化合物成分，和各种已发表的载体蛋白和接合技术进行了讨论。应谨慎选择成分和技术，以构建负担得起的A型链球菌候选疫苗，特别是为低收入和中等收入国家（LMIC）。为此，新的技术进行了讨论，如生物共轭与PglB的鼠李糖聚合物共轭和膜抗原（GMMA）的通用模块，特别是作为低成本的解决方案，疫苗生产的前景。包含物种特异性聚糖和蛋白质组分的“双重打击”缀合物的合理设计将是有益的，并且产生靶向A型链球菌定殖而不引起自身免疫应答的保守疫苗将是理想的。
The Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) or Streptococcus pyogenes. It is a conserved and simple polysaccharide, comprising a rhamnose backbone and GlcNAc side chains, further decorated with glycerol phosphate on approximately 40% GlcNAc residues. Its conservation, surface exposure and antigenicity have made it an interesting focus on Strep A vaccine design. Glycoconjugates containing this conserved carbohydrate should be a key approach towards the successful mission to build a universal Strep A vaccine candidate. In this review, a brief introduction to GAC, the main carbohydrate component of Strep A bacteria, and a variety of published carrier proteins and conjugation technologies are discussed. Components and technologies should be chosen carefully for building affordable Strep A vaccine candidates, particularly for low- and middle-income countries (LMICs). Towards this, novel technologies are discussed, such as the prospective use of bioconjugation with PglB for rhamnose polymer conjugation and generalised modules for membrane antigens (GMMA), particularly as low-cost solutions to vaccine production. Rational design of “double-hit” conjugates encompassing species specific glycan and protein components would be beneficial and production of a conserved vaccine to target Strep A colonisation without invoking an autoimmune response would be ideal.
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影响因子：
3.5
作者：
Castro SA;Dorfmueller HC
通讯作者：
Dorfmueller HC
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Korotkova, Natalia
影响因子：
12.8
作者：
Faé, KC;Oshiro, SE;Guilherme, L
通讯作者：
Guilherme, L
DOI：
10.1016/s0174-3031(83)80051-1
发表时间：
1983-01-01
期刊：
ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY
影响因子：
--
作者：
HAMADA, S;OKAHASHI, N;MCGHEE, JR
通讯作者：
MCGHEE, JR