Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants.
Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants.
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乳腺癌转移的分子生物学。炎性乳腺癌：临床综合征和分子决定因素。
DOI：
10.1186/bcr89
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Merajver SD
中科院分区：
文献类型：
--
作者：
Kleer CG;van Golen KL;Merajver SD
炎症性乳腺癌(IBC)是一种侵袭性的局部晚期乳腺癌(LABC)，在美国每年约有5%的乳腺癌患者受到影响。它是一种临床和病理上截然不同的LABC形式，尤其是生长迅速、侵袭性和血管生成。几乎所有女性在确诊时都有淋巴转移，大约36%的女性有严重的远处转移。尽管最近在综合治疗方面取得了进展，但IBC患者的预后很差，中位无病生存期不到2.5年。最近对IBC表型背后的遗传决定因素的研究导致了与这种疾病的发展和进展有关的基因的确定。这项工作得到了人类原代细胞系和动物模型的建立的帮助。这些进展为今后IBC的诊断和治疗提供了新的干预目标。
Inflammatory breast cancer (IBC) is an aggressive form of locally advanced breast cancer (LABC) that effects approximately 5% of women with breast cancer annually in the USA. It is a clinically and pathologically distinct form of LABC that is particularly fast growing, invasive, and angiogenic. Nearly all women have lymph node involvement at the time of diagnosis, and approximately 36% have gross distant metastases. Despite recent advances in multimodality treatments, the prognosis of patients with IBC is poor, with a median disease-free survival of less than 2.5 years. Recent work on the genetic determinants that underlie the IBC phenotype has led to the identification of genes that are involved in the development and progression of this disease. This work has been aided by the establishment of primary human cell lines and animal models. These advances suggest novel targets for future interventions in the diagnosis and treatment of IBC.
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影响因子：
8.8
作者：
Forozan, F;Veldman, R;Ammerman, CA;Parsa, NZ;Kallioniemi, A;Kallioniemi, OP;Ethier, SP
通讯作者：
Ethier, SP
DOI：
10.1073/pnas.88.11.5006
发表时间：
1991-06-01
影响因子：
11.1
作者：
DAVIDOFF, AM;HUMPHREY, PA;MARKS, JR
通讯作者：
MARKS, JR
影响因子：
45.3
作者：
Merajver, SD;Weber, BL;Pierce, LJ
通讯作者：
Pierce, LJ
影响因子：
2.5
作者：
Ethier, Stephen P.
通讯作者：
Ethier, Stephen P.
DOI：
10.1073/pnas.95.2.548
发表时间：
1998-01-20
影响因子：
11.1
作者：
Achen, MG;Jeltsch, M;Stacker, SA
通讯作者：
Stacker, SA