Arterial Stiffness, Biomarkers of Liver Fat, and the Development of Metabolic Dysfunction in Metabolically Healthy Population: A Prospective Study.
Arterial Stiffness, Biomarkers of Liver Fat, and the Development of Metabolic Dysfunction in Metabolically Healthy Population: A Prospective Study.
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动脉僵硬、肝脏脂肪生物标志物以及代谢健康人群代谢功能障碍的发展：一项前瞻性研究
DOI：
10.3389/fcvm.2022.928782
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发表时间：
2022
影响因子：
3.6
通讯作者：
Chen, Yuhong
中科院分区：
文献类型：
--
作者：
Lin, Lin;Wang, Long;Du, Rui;Hu, Chunyan;Lu, Jieli;Wang, Tiange;Li, Mian;Zhao, Zhiyun;Xu, Yu;Xu, Min;Bi, Yufang;Wang, Weiqing;Ning, Guang;Chen, Yuhong
已知代谢功能障碍与动脉僵硬度相关。然而，由于动脉硬化和潜在的机制，代谢综合征和糖尿病的风险仍然不清楚。我们的目的是研究动脉硬化与代谢综合征和糖尿病风险的关系，并确定这种关系是否由肝脏脂肪介导。对4,139名基线时代谢健康的中国成年人进行了一项前瞻性研究。动脉僵硬度测量臂踝脉搏波速度（baPWV）。肥胖定义为体重指数≥25 kg/m2。主要结局为代谢综合征和糖尿病。在平均4.4年的随访期间，分别有1，022名（24.7%）和354名（9.5%）参与者发展为代谢综合征和糖尿病。与baPWV最低四分位数的受试者相比，最高四分位数的受试者患代谢综合征和糖尿病的风险分别高出85%和91%[代谢综合征的风险比（RR）1.85，95%置信区间（CI）1.41，2.42;糖尿病的RR 1.91，95% CI 1.16，3.15]。中介分析表明，脂肪肝显著介导了动脉硬化与代谢综合征和糖尿病风险的相关性。具体来说，18.4%的代谢综合征和12.6%的糖尿病风险是由动脉硬化引起的，这些风险是通过脂肪肝介导的。肥胖者的动脉硬化与代谢综合征和糖尿病的高风险相关。这种关联可能部分由脂肪肝介导。
Metabolic dysfunction is known to be associated with arterial stiffness. However, the risks of metabolic syndrome and diabetes due to arterial stiffness and the potential mechanism remain unclear. We aimed to investigate the association of arterial stiffness with the risk of metabolic syndrome and diabetes, and determine whether this association is mediated by liver fat. A prospective study was conducted with 4,139 Chinese adults who were metabolically healthy at baseline. Arterial stiffness was measured by brachial–ankle pulse wave velocity (baPWV). Obesity was defined as body mass index ≥25 kg/m2. The primary outcomes were incident metabolic syndrome and diabetes. During a median follow-up of 4.4 years, 1,022 (24.7%) and 354 (9.5%) participants developed metabolic syndrome and diabetes, respectively. Compared with those in the lowest quartile of baPWV, participants in the highest quartile had 85 and 91% higher risks of metabolic syndrome and diabetes [risk ratio (RR) 1.85, 95% confidence interval (CI) 1.41, 2.42 for metabolic syndrome; RR 1.91, 95% CI 1.16, 3.15 for diabetes]. Mediation analyses indicated that fatty liver significantly mediated the association of arterial stiffness with metabolic syndrome and diabetes risk. Specifically, 18.4% of metabolic syndrome and 12.6% of diabetes risk due to arterial stiffness were mediated through fatty liver. Arterial stiffness was associated with higher risks of metabolic syndrome and diabetes in individuals with obesity. This association may be partially mediated by fatty liver.
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影响因子：
39.3
作者：
Paneni F;Beckman JA;Creager MA;Cosentino F
通讯作者：
Cosentino F
影响因子：
9.8
作者：
Adams, Leon A.;Harmsen, Scott;St Sauver, Jennifer L.;Charatcharoenwitthaya, Phunchai;Enders, Felicity B.;Therneau, Terry;Angulo, Paul
通讯作者：
Angulo, Paul
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
37.8
作者：
Dekker, JM;Girman, C;Heine, RJ
通讯作者：
Heine, RJ
异位脂肪、胰岛素抵抗和非酒精性脂肪肝对心血管疾病的影响
DOI：
10.1161/atvbaha.114.303034
发表时间：
2014-06-01
影响因子：
8.7
作者：
Byrne, Christopher D.;Targher, Giovanni
通讯作者：
Targher, Giovanni