Molecular logic of neocortical projection neuron specification, development and diversity.

Molecular logic of neocortical projection neuron specification, development and diversity.
复制标题

DOI:
10.1038/nrn3586
复制
发表时间:
2013-11
影响因子:
34.7
通讯作者:
Macklis, Jeffrey D.
Macklis, Jeffrey D.
中科院分区:
医学1区
文献类型:
--
作者:
Greig, Luciano Custo;Woodworth, Mollie B.;Galazo, Maria J.;Padmanabhan, Hari;Macklis, Jeffrey D.

文献摘要

参考文献

被引文献

相似文献

新皮层的复杂回路是由发育过程中在精确的分子调控下产生的各种神经元亚型组成的。近年来,已经确定了几个关键控制的规范和分化的新皮层投射神经元。这项工作提供了实质性的洞察“分子逻辑”的皮质发育,越来越多地支持一个模型,其中个人的祖细胞阶段和有丝分裂后的监管机构嵌入在高度互连的网络门顺序的发展决策。在这里,我们提供了一个综合帐户的分子控制,直接逐步发展和划定的亚型和区域身份的新皮层投射神经元。
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the “molecular logic” underlying cortical development, increasingly supporting a model in which individual progenitor-stage and postmitotic regulators are embedded within highly-interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.
DOI: 10.1073/pnas.1002285107
发表时间: 2010-07-20
影响因子: 11.1
作者:
Bedogni, Francesco;Hodge, Rebecca D.;Hevner, Robert F.
通讯作者: Hevner, Robert F.
DOI: 10.1073/pnas.0509032102
发表时间: 2005-12-06
影响因子: 11.1
作者:
Chen, JG;Rasin, MR;Sestan, N
通讯作者: Sestan, N
DOI: 10.1006/dbio.2001.0422
发表时间: 2001-11-01
影响因子: 2.7
作者:
Cobos, I;Puelles, L;Martínez, S
通讯作者: Martínez, S
DOI: 10.1038/nn.2427
发表时间: 2009-11
影响因子: 25
作者:
Chou SJ;Perez-Garcia CG;Kroll TT;O'Leary DD
通讯作者: O'Leary DD
DOI: 10.1016/j.neuron.2007.12.012
发表时间: 2008-02-07
期刊: NEURON
影响因子: 16.2
作者:
Alcamo, Elizabeth A.;Chirivella, Laura;McConnell, Susan K.
通讯作者: McConnell, Susan K.